Newborn PPH from antidepressant use?
A cohort study in a large group of publicly insured women seems to indicate that using selective serotonin reuptake inhibitors (SSRI) late in pregnancy may increase the risk of persistent pulmonary hypertension in a newborn.
Researcher used the Medicaid Analytic eXtract for 46 states and Washington DC from 2000 to 2010, with a last follow-up date of December 21, 2010. The pool included 3,789,330 pregnant women who were enrolled in Medicaid from 2 months or fewer after the date of their last menstrual period to at least 1 month after delivery. The source cohort included only women with a diagnosis of depression.
A total of 128,950 (3.4%) women had filled at least 1 prescription of antidepressants late in pregnancy, 102,179 (2.7%) of whom used an SSRI and 26,771 (0.7%) of whom used a non-SSRI. Among the babies not exposed to antidepressants, 7630 were diagnosed with pulmonary hypertension (20.8 per 10,000 births; 95% confidence interval [CI], 20.4-21.3 per 10,000 births) compared with 322 infants exposed to SSRIs (31.5; 95% CI, 28.3-35.2 per 10,000 births) and 78 infants exposed to non-SSRIs (29.1; 95% CI, 23.3-36.4 per 10,000 births).