An analysis by Danish investigators published in JAMA shows that taking oral fluconazole during pregnancy is associated with a significant increased risk of spontaneous abortion. Plus: What persuades parents to vaccinate for HPV? Also: Does prenatal exposure to lithium increase risk of congenital malformations?
Pregnancy and Birth
Mother-to-child transmission of HIV in the United States can be eliminated with the help of obstetricians.
A patient filed a lawsuit on behalf of her child alleging negligence by her obstetrician in delaying the delivery when she was in the hospital contracting and had severe abdominal pain. Thus, her uterus was allowed to rupture, which caused the child’s severe brain injury. Plus more malpractice cases.
A recent study compared pretreatment with mifepristone followed by treatment with misoprostol against treating with misoprostol alone for the management of first-trimester pregnancy loss. Plus: Are patients less satisfied with MDs who reduce opioids? Also: Does infant exposure to hypertensive disorders or pregnancy affect neurodevelopment?
Altered maternal vaginal microbiota composition contributes to the pathophysiology of preterm birth (PTB), according to a study of two racially distinct cohorts of US pregnant women.
In cases of very preterm birth, waiting at least 2 minutes to clamp the umbilical cord, coupled with immediate neonatal care with the cord intact, improved outcomes, according to a multicenter study.
The first birth from a groundbreaking trial of in utero stem cell transplantation suggests that fetal therapy may be a viable new option for alpha thalassemia (ATM). Plus: Why do vasomotor symptoms bother some women long after menopause? Also: Does CPAP improve sexual QOL in women with sleep apnea?
A recent study shows that mothers exposed to moderate to high levels of caffeine during pregnancy may give birth to infants that gain excess weight in early childhood. Plus: How does ART affect risk of stillbirth? Also: A study found that obese African-American women have significantly lower energy expenditure per kilogram of mass compared to obese white women with similar energy intake and physical activity levels.
Maternal chronic hepatitis B virus (HBV) infection is associated with a 16% increase in risk of preterm birth (PTB), with substantial heterogeneity, according to an updated systematic review and meta-analysis.
The fetal fibronectin (fFN) test alone had a sensitivity of 66.7% and a specificity of 97.2% in predicting spontaneous preterm birth (SPTB) in symptomatic twin pregnancies, according to a small pilot study of 40 women.