Researchers are about to launch a large, multinational Phase III clinical trial to test the safety and effectiveness of a vaginal ring containing the experimental antiretroviral (ARV) drug dapivirine. The ring is intended to provide women with another means to prevent HIV acquisition through vaginal intercourse.
For the first time, we have a drug in our arsenal to help prevent the spread of HIV infection to uninfected individuals.
Use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy is associated with smaller fetal head circumference-a prenatal marker of brain volume-and with higher risk of preterm birth (< 37 weeks), according to findings from a prospective population-based study from the Netherlands.
Analysis by the United States Food and Drug Administration (FDA) of compounded 17Î±-hydroxyprogesterone caproate (17P) shows the samples meet the potency and total purity standards for Makena, the branded version of the drug. Testing was done on 16 samples of bulk 17P active pharmaceutical ingredients (API) in response to questions from K-V Pharmaceuticals, Makenaâ€™s sponsor, about potency and purity of the compounded product.
Venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism, is one of the most common, serious complications associated with pregnancy.
Gestational diabetes mellitus (GDM) is glucose intolerance with onset or first recognition during pregnancy. African American, Hispanic, and Native American women have a higher incidence of GDM, although studies indicate that socioeconomic status may be more strongly associated with GDM than race or ethnicity.
An estimated 12 million woemn in the United States use the oral contraceptive (OC) pill, making it the most popular reversible method of birth control. Many new hormonal delivery systems offer benefit superior to those of the pill. The vaginal ring, injection, and patch allow less-frequent dosing, which may improve compliance. The intrauterine device and implant are significantly more effective than the pill, with failure rates rivaling those of sterilization. Nevertheless, the pill remains the method of choice for the majority of women, and pharmaceutical companies are therefore eager to develop new formulations. Since the pill was first introduced more than 50 years ago, many of these new formulations have been little more than updated packaging. However, several new brands have emerged recently that are advertised as having noncontraceptive benefits beyond those of older pill formulations, as well as improved bleeding and side-effect profiles.
Commercial insurers are instituting programs to allow physicians to preferentially prescribe the compounded 17-OHP.
This article reviews the indications for clomiphene citrate, typical ovulation and conception rates, complications, side effects, alternative pharmacologic options.
Nearly half of women 18 to 44 years old use prescription drugs. Therefore clinicians must be prepared to counsel these patients regarding medication use during conception and pregnancy.