A diagnosis of vulvovaginal atrophy (VVA) in breast cancer survivors is associated with a significant increase in the burden of illness and social costs, according to an Italian Delphi Panel in the journal Supportive Care in Cancer. These findings are primarily due to a rise in comorbidities and resource utilization, but adequate treatment might reduce the impact of the condition.
Affecting roughly 50% of all postmenopausal women, VVA is magnified by longer life expectancy, with many women spending more than one-third of their life in the postmenopausal state. However, despite the substantial negative impact it has on quality of life, there is a disparity between VVA’s high prevalence and infrequent clinical diagnosis, which has been documented in medical practice and in surveys.
In large part, this discrepancy is believed to be the result of patients unwilling and/or reluctant to report symptoms in the clinical setting and the difficulty healthcare professionals have in approaching this sensitive topic during routine consultations. “The result of this underdiagnosis is a chronic condition that may not be addressed for a long time and, therefore, Is more likely to undergo progression when left untreated,” the Italian authors wrote.
The Delphi Panel, which was conducted in response to the lack of published evidence on VVA in Italy, evaluated the epidemiology of VVA; the risk factors/comorbidities; the current standard of care and unmet medical needs; the comparison between recent US epidemiological data and the Italian patient population; and the health resources used for VVA and breast cancer.
The Panel also collected information on the experience of participants with new treatments for VVA, such as ospemifene, and how these treatments are perceived in their capability to reduce symptoms associated with VVA. A questionnaire was sent via email to all participants in Italy in November 2016, followed by a 1-day panel convened in Milan on November 24, 2016. Two additional rounds of follow-up interviews took place in January and July 2017, with final analyses completed in December 2018.