A large population-based cohort study in the American Journal of Obstetrics & Gynecology (AJOG) has concluded that maternal prepregnancy impaired fasting glucose (IFG) increases risk of preterm birth (PTB), as well as either large or severe large for gestational age birth.
“It is now well accepted that reducing blood glucose in pregnancy reduces pregnancy and postpartum complications,” said principal investigator James Tang, PhD, an associate professor of maternal and child health at Guangzhou Medical University in Guangdong Province, China. “However, very few studies have investigated the impact of prepregnancy hyperglycemia on adverse pregnancy outcomes.”
Previous studies have suggested there are effective interventions for IFG, which reduce the mortality and delay the onset of diabetes.
“From the perspective of health management and disease prevention, identifying the association of IFG to adverse pregnancy outcomes is of substantial public health importance because it might be relatively easy to implement health interventions, plus helpful in decreasing the risk of adverse pregnancy outcomes in mothers who have IFG before pregnancy,” Dr. Tang told Contemporary OB/GYN.
The cohort study consisted of 640,469 Chinese women from the National Free Preconception Health Examination Project (NFPHEP) who delivered singleton births in Guangdong Province from January 2013 to December 2017. Of the total participants, 4.84% met the World Health Organization (WHO)’s cut-point for IFG (fasting glucose concentration ≥ 6.1 mmol/L or greater and < 7.0 mmol/L), 5.10% had PTB, 1.12% had early PTB, 7.11% had large for gestational age (LGA) birth and 2.53% had severe large for gestational age (SLGA) birth. (SLGA was defined as birth weight by gestational age > 97th percentile.)
Dr. Tang reports no relevant financial disclosures.