March 21st 2024
GlaxoSmithKline's phase 3 trial demonstrated promising overall and progression-free survival outcomes in patients with primary advanced or recurrent endometrial cancer, paving the way for potential FDA approval.
Dysplastic changes in prophylactically removed Fallopian tubes of women inclined to ovarian cancer
September 23rd 2011The aim of this study was to investigate the occurrence of (pre)neoplastic lesions in overtly normal Fallopian tubes from women predisposed to developing ovarian carcinoma. The presence of (pre)neoplastic lesions was scored in histological specimens from 12 women with a genetically determined predisposition for ovarian cancer, of whom seven tested positive for a germline BRCA1 mutation.
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'Nuns, virgins, and spinsters'. Rigoni-Stern and cervical cancer revisited
September 23rd 2011The view that nuns have a very low risk of cervical cancer is questioned. The historical evidence for this view is reviewed, from the beginning of the eighteenth century to the present. An estimate of the actual mortality rate from cervical cancer suggests that risk of death from this neoplasm among nuns is little different from that among the general female population.
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Results Continue to Affirm Ampersand’s Cervical-Cancer Screen Outperforms Conventional Pap Test
September 23rd 2011A fast, fully automated bio-chemical system for detecting cervical cancer, developed by Ampersand Medical Corp. (OTC BB: AMPM), is capable of identifying the disease with greater accuracy than is routinely reported by Pap testing, concludes a presentation made today here at the 14th International Congress of Cytology.
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Study Points to Ampersand’s InPath In-Cell HPV as the First Test To Identify Cancer-Causing HPV
September 23rd 2011With more than 24 million U.S. women diagnosed annually with human papillomavirus (HPV), the cause of virtually all cervical cancer, Ampersand Medical Corp.’s new screening technique shows promise to identify those patients that truly need to be monitored.
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A guide to Women's Health on the Internet Part 1: Pregnancy, childbirth and ultrasound
September 23rd 2011In this column, subject experts have been invited to provide an annotated guide to some of the most useful health sites on the Internet. In this issue Hans van der Slikke, Consultant Obstetrician at Zaandam Hospital, The Netherlands, and Chairman of the International Council of OBGYN.net, provides a guide to some of the best women's health resources now available on the Internet.
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Anatomy of the Autonomic Innervation of the Pelvic Organs Some considerations for pelvic surgeons
September 23rd 2011The innervation of the pelvic structures has an important role in the surgical knowledge, especially when the surgeon is dealing with radical surgery for cancer and with extensive surgical procedures for deep infiltrating endometriosis.
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Laparoscopic End-to-End Reanastomosis on the Distal Ureter
September 23rd 2011Laparoscopy succeed in overcoming technical difficulties and poor outcome of traditional open ureteroureteral distal anastomosis. A technique for laparoscopic repair of injury involving the distal ureter has been successfully developed.
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Ovarian Cancer And The Search For Early Detection
September 22nd 2011Susan is a 58-year-old woman who saw her family physician after a few weeks of mild abdominal pain and bloating. The examination of her abdomen was normal, as was a pelvic and rectal exam. Blood tests for infection, liver and gall bladder problems were also normal.
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Treatment Of Cervical Dysplasia
September 22nd 2011There are many ways to treat cervical dysplasia (CIN). Factors influencing the choice of treatment for cervical dysplasia include the extent and severity of the dysplasia, the age of the woman, and whether or not she has any other gynecological problems.
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Laparoscopic-Assisted Vaginal Hysterectomy
September 22nd 2011We compared laparoscopic-assisted vaginal hysterectomy (LAVH) with total abdominal hysterectomy (TAH) in a case control study that evaluated length of operation, blood loss, length of hospital stay, drug requirements for pain, and postoperative pain and activity levels.
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Uncommon Sarcomas of the Uterine Cervix: A Review of Selected Entities
September 22nd 2011Sarcomas constitute less than 1% of all cervical malignancies. With over 150 reported cases, rhabdomyosarcomas represent the most commonly reported sarcoma at this location. In this report, a select group of the more uncommon sarcomas of the uterine cervix are reviewed, including all previously reported examples of leiomyosarcoma, liposarcoma, alveolar soft part sarcoma, Ewing sarcoma/primitive neuroectodermal tumor, undifferentiated endocervical sarcoma, and malignant peripheral nerve sheath tumor (MPNST).
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Studies Explore New Modalities for Screening of Endometrial and Cervical Cancers
September 22nd 2011Researchers at University Hospital CASE Medical Center (UHCMC) in Cleveland, Ohio have embarked on new clinical studies that explore early detection of endometrial and cervical cancers in women. Results of these breakthrough studies could save countless lives and extend the average life expectancy in women.
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Quality of Health Information for Cervical Cancer Treatment on the Internet
September 22nd 2011The internet has become a frequently used and powerful tool for patients seeking medical information. This information may not undergo the same quality consideration as the peer-review criteria for publication of information in a journal.
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ASC-H in Pap test- definitive categorization of cytomorphological spectrum
September 22nd 2011The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for management of ASC-H is colposcopic examination followed by biopsy. HPV testing (HPVT) is recommended after a negative biopsy result.
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Radiation-Sparing Managements for Cervical Cancer: A Developing Countries Perspective
September 22nd 2011Cervical cancer is the seventh most frequent cancer worldwide but more than 80% of cases occur in developing countries. Till date, radiation therapy with external beam and brachytherapy remains as the core treatment for most stages of cervical cancer.
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Gynecologic Oncology Patients' Satisfaction and Symptom Severity During Palliative Chemotherapy
September 22nd 2011Research on quality and satisfaction with care during palliative chemotherapy in oncology patients has been limited. The objective was to assess the association between patient's satisfaction with care and symptom severity and to evaluate test-retest of a satisfaction survey in this study population.
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Cervical Cancer with Human Papilloma Virus and Epstein Barr Virus Positive
September 22nd 2011The Early-7 (E7) protein of HPV binds to the underphosphorelated form of the tumor suppressor protein - pRb and displaces the E2F transcription factor that is normally bound by pRb. The latent membrane protein-1 (LMP-1) of EBV prevents apoptosis of B cells by up regulating the expression of bcl-2, and it activates growth promoting pathway that are normally triggered by T cell - derivate signal.
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WT1 Gene Expression as a Prognostic Marker in Advanced Serous Epithelial Ovarian Carcinoma
September 22nd 2011WT1 is a tumor suppressor gene responsible for Wilms' tumor. WT1 reactivity is limited to ovarian serous carcinomas. Recent studies have shown that WT1 plays an important role in the progression of disease and indicates a poorer prognosis of human malignancies such as acute myeloid leukemia and breast cancer.
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Laparoscopic Management of Fallopian Tube Prolapse Masquerading as Adenocarcinoma of the Vagina
September 22nd 2011Fallopian tube prolapse as a complication of abdominal hysterectomy is a rare occurrence. A case with fallopian tube prolapse was managed by a combined vaginal and laparoscopic approach and description of the operative technique is presented.
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Epigenetics of cervical cancer. An overview and therapeutic perspectives
September 22nd 2011Cervical cancer remains one of the greatest killers of women worldwide. It is difficult to foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic drugs, surgery, and radiation; therefore, testing of molecular targeted therapies against this malignancy is highly desirable.
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The Correlation Between Lifestyle, Nutrition, Vitamin Deficiency and HPV Induced Cervical Changes
September 22nd 2011Human Papillomavirus has emerged as a distinct cause of cervical changes in young women. Its prevalence is continuously growing and is considered at epidemic proportions with 20 million Americans already infected and 5.5 million new cases reported annually. (2) (Center for Disease Control and Prevention, Tracking the Hidden Epidemics., Trends in STDs in the U.S. 2000, Atlanta, Georgia, 2000)
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Reduced Expression of Multiple Gap Junction Proteins is a Feature of Cervical Dysplasia
September 22nd 2011Cervical dysplasia is a premalignant lesion associated with human papillomavirus (HPV) infection which, over time, can turn cancerous. Previous studies have indicated that loss of gap junctions may be a feature of cervical cancer and premalignant dysplasia.
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HPV Vaccine Shows Efficacy in Less Than Three Doses
September 15th 2011Prophylactic human papillomavirus vaccines have been shown to be effective in reducing the disease burden of cervical cancer, but the three dose regimen can be expensive and difficult to complete. With that in mind, Dr Aimée R. Kreimer, investigator in the division of cancer epidemiology and genetics at the National Cancer Institute, the National Institute of Health, and colleagues sought to determine if less than three doses of the vaccine would be effective. The results are published in the Journal of the National Cancer Institute.
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Dangers of Radiation and Radiation Exposure During Pregnancy
September 14th 2011In light of ongoing threats of radiation exposure during the earthquake, tsunami, and nuclear crisis in Japan, OBGYN.net has put together a list of resources and information for doctors and patients who want to learn more about the dangers of radiation and exposure during pregnancy.
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