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Noninvasive Prenatal Testing
NIPT genome analysis for predicting cancer
June 21, 2021
A retrospective analysis has found that comprehensive examination of shallow-sequenced, whole-genome cell-free DNA (cfDNA) allows for the incidental detection of maternal tumors, with relatively high precision.
Confined placental mosaicism and pregnancy
June 21, 2021
The association between confined placental mosaicism (CPM) and prenatal growth and adverse pregnancy outcomes is significant, according to a literature review in the journal Human Reproduction Update.
Fetal blood group genotype for managing hemolytic disease of fetus and newborn
May 05, 2021
A systematic review and meta-analysis on the benefits of non-invasive prenatal testing (NIPT) for detecting hemolytic disease of fetus and newborn (HDNF) validates routing anti-D prophylaxis.
Whole genome sequencing of cell-free DNA for NIPT
May 05, 2021
An analysis of a large cohort of patients who chose noninvasive prenatal testing (NIPT) as a screening method for fetal trisomy 21, 18, and 13 (T21, T18 and T13) and sex chromosome aneuploidies (SCA) concluded there were extremely high detection rates and exceptionally low false positive rates.
Economic impact of coverage expansion for NIPT
April 15, 2021
Expanding coverage for noninvasive prenatal testing (NIPT) through a performance-based, risk-sharing agreement (PBRSA) resulted in a significant increase in NIPT use, a significant decrease in conventional prenatal screening methods, and a negligible increase in per member per month (PMPM) cost at Harvard Pilgrim Health Care (HPHC) in New England.
Emotions about testing negative with NIPT
March 09, 2021
A small percentage of women whose noninvasive prenatal testing (NIPT) results were negative regretted taking the test and blamed themselves, according to a 1-year postpartum questionnaire survey.
Cost of cell-free DNA noninvasive testing for Down syndrome
March 09, 2021
A public health screening program for Down syndrome in Quebec, Canada, found that cell-free DNA noninvasive prenatal testing (NIPT) could be implemented at the same cost as the current screening program, according to computer simulations.
How insurance impacts access to NIPT
March 08, 2021
Some women are unable to choose noninvasive prenatal testing (NIPT), due to lack of insurance coverage, according to a pilot study in the Journal of Community Genetics.
Sonographic abnormalities in pregnancies after IVF
February 24, 2021
Preimplantation genetic testing for aneuploidy (PGT-A) is not associated with a difference in risk of fetal anomaly detected on mid-trimester anatomical survey, according to a study.
Expanding scope of noninvasive prenatal testing
February 23, 2021
“Our results can further inform the debate on the future uses of NIPT and future policy of its implementation,” said co-principal investigator Hazar Haidar, PhD, a lecturer in bioethics at Université du Québec à Montréal (UQAM), Montréal, Canada.