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A detailed look at the design and outcomes of the monkey trial on tibolone, by Drs. Tom Clarkson and Leon Speroff. Available only online in conjunction with the authors' article, "Is tibolone a viable alternative to HT?" in our August 2003 issue.

A large body of research suggests that tumors in hormone users are better-differentiated and of lower grade and stage, with better outcomes. The contrary findings from WHI may reflect the older age of the participants and a need to discontinue HT 2 weeks before mammography in women aged 65 and older with dense breasts.

Clinical experience in humans in many countries and studies in monkeys say yes. Tibolone offers the symptom relief and bone benefits of CEE with endometrial safety--without stimulating breast tissue or increasing the risk of CAD.

Before choosing the appropriate surgical procedure, a two-pronged approach--transvaginal ultrasonography and CA-125 assessment--is the best way to determine the benign or malignant nature of an ovarian mass.

Drug therapy isn't recommended for all women with osteopenia, a precursor to osteoporosis. Clinicians need to identify, early on, the patients with low bone mass at additional risk for future osteoporotic fractures.

Patients need an individualized approach, says this expert in pelvic reconstructive surgery. Many factors determine whether minimally invasive versus invasive surgery, or abdominal versus vaginal routes of repair are best.

When should a patient who menstruates normally be diagnosed as having polycystic ovary syndrome, and what clinical differences exist between these somewhat atypical women and those with classic PCOS?

Therapeutic amenorrhea is not always easy to initiate or to maintain. But anticipating prolonged, heavy bleeding in patients with certain medical problems--and managing it prophylactically--is far better than trying to stop potentially life-threatening bleeding once it's begun.

Rational decision-making and raging adolescent hormones do sound like strange bedfellows. But research reveals some ways ob/gyns can help teens make wiser choices--and grow into healthy sexual adults.

A critical look at black cohosh, soy, chasteberry, and related supplements finds some evidence to support their use, but randomized large-scale clinical trials to definitively prove their worth are sorely needed.

Consider the pros and cons before adding cosmetic procedures, advises this article from Medical Economics OB/GYN edition.

A diagnostic work up holds the challenge of ruling out uterine malignancy and hyperplasia, as well as pinpointing the noncancerous cause of the bleeding. An expert in the field outlines the most appropriate assessment tools to help accomplish these goals.