Ampicillin remains poor choice for antepartum pyelonephritis
Antimicrobial susceptibility patterns of gram-negative rods causing antepartum pyelonephritis have shown little change over the last 15 years. Susceptibility patterns in 1992 to 1993 and 2004 to 2006 were similar, with 51% and 54% (respectively) of the Escherichia coli strains being resistant to ampicillin, according to Roberts and colleagues from Metrohealth Medical Center in Cleveland. However, E coli resistance to trimethoprim-sulfamethoxazole increased from 5% to 20%. No resistance to first-generation cephalosporins was reported. This study confirms that ampicillin is a poor choice for the treatment of antepartum pyelonephritis.
Antimicrobial susceptibility patterns of gram-negative rods causing antepartum pyelonephritis have shown little change over the last 15 years. Susceptibility patterns in 1992 to 1993 and 2004 to 2006 were similar, with 51% and 54% (respectively) of the Escherichia coli strains being resistant to ampicillin, according to Roberts and colleagues from Metrohealth Medical Center in Cleveland. However, E coli resistance to trimethoprim-sulfamethoxazole increased from 5% to 20%. No resistance to first-generation cephalosporins was reported. This study confirms that ampicillin is a poor choice for the treatment of antepartum pyelonephritis.
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Trimethoprim–sulfamethoxazole not found to increase infant birth weight in HIV cases
July 9th 2025A recent randomized trial found no significant improvement in birth weight or key birth outcomes from antenatal trimethoprim–sulfamethoxazole prophylaxis in human immunodeficiency virus-positive pregnant women.
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