Antidepressant use increases the risk for miscarriage

Article

Pregnant women who are taking antidepressants are at a 68% greater risk for miscarriage than women not taking the drugs, a nested, case-control study from Quebec reports.

Pregnant women who are taking antidepressants are at a 68% greater risk for miscarriage than women not taking the drugs, a nested, case-control study from Quebec reports.

Researchers included data on 5,124 women who had had clinically verified miscarriages up to 20 weeks' gestation and a large sample of women who had not miscarried. Of those who miscarried, 5.5% had taken at least 1 antidepressant during the pregnancy versus 2.7% of those who did not.

Use of a selective serotonin reuptake inhibitor increased the risk by about 61% (odds ratio [OR]. 1.61; 95% CI, 1.28-2.04). Serotonin-norepinephrine reuptake inhibitors more than doubled the risk (OR, 2.11; 95% CI, 1.34-3.30). Further, combined use of more than 1 antidepressant from different classes more than tripled the risk (OR, 3.51; 95% CI 2.20-5.61). The risk of miscarriage associated with use of these categories of antidepressants was significantly higher than with solo therapy with tricyclic antidepressants or other classes of antidepressants (adjusted OR, 1.27-1.53; P<.05).

Recent Videos
Dr. Somi Javaid highlights disparities in sexual health | Image Credit: hermd.com.
How advancements in IVF are impacting embryologist workload and patient care | Image Credit: fertility.coopersurgical.com/our_experts
Study finds no causal link between maternal health in pregnancy and autism risk | Image Credit: med.nyu.edu/faculty.
Mirvie's RNA platform revolutionizes detection of fetal growth restriction | Image Credit: wexnermedical.osu.edu
How early genetic testing empowers parents and improves outcomes | Image Credit: tuftsmedicine.org
Dallas Reed highlights trends and barriers in prenatal genetic testing | Image Credit: tuftsmedicine.org
How maternal fetal medicine specialists improve outcomes for high-risk pregnancies | Image Credit: profiles.mountsinai.org
How the cobas liat assay panels improve STI detection | Image Credit: labqualityconfab.
Screening-to-diagnosis interval vital for gestational diabetes outcomes | Image Credit: ultracon2024.eventscribe.net
Henri M. Rosenberg, MD
Related Content
© 2025 MJH Life Sciences

All rights reserved.