According to a new study in Gynecologic Oncology, women who have polycystic ovary syndrome (PCOS) may be at greater risk of developing some types of cancer.
According to a new study in Gynecologic Oncology, women who have polycystic ovary syndrome (PCOS) may be at greater risk of developing some types of cancer.
Researchers at the Danish Cancer Society Research Center used the Danish National Patient Register to identify 12,070 women who were diagnosed with PCOS from 1977 to 2012 when they were aged 9 to 49 years. The Danish Cancer Registry was used to follow the cohort through 2012 and compare the incidence of cancer in the cohort against the general Danish female population using standardized incidence rations (SIRs).
Resident's blog: Focusing on the patient while under pressure
During the course of study, cancer was diagnosed in 279 women with PCOS (SIRâ =â 1.19; 95% confidence interval [CI]â =â 1.06–1.34). A nearly fourfold increased risk of endometrial cancer was found (numbers observed [N]â =â 16, SIRâ =â 3.9; 95% CIâ =â 2.2–6.3), which confirms prior findings. Most of the endometrial cancer cases were type 1 (Nâ =â â 14, SIRâ =â 4.7; 95% CIâ =â 2.6–7.9). The researchers did note however that the excess absolute risk of 13.1 per 100,000 person-years would represent just a few extra cases of endometrial cancer in PCOS patients than in those who don’t have the syndrome. No apparent association was seen between PCOS and breast (Nâ =â 59, SIRâ =â 1.1; 95% CIâ =â 0.8–1.4) or ovarian cancer (Nâ =â 10, SIRâ =â 1.8; 95% CIâ =â 0.8–3.2). Increased numbers of women with brain (8.2 cases expected vs 18 observed), kidney (1.6 cases expected vs 6 observed), and colon cancer (5.2 cases expected vs 11 observed) were also noted.
The investigators concluded that their results add further support that women with PCOS are at increased risk of endometrial cancer. They also urge further study on the increased risk of brain, colon, and kidney cancer in women with PCOS.
To get weekly advice for today's Ob/Gyn, subscribe to the Contemporary OB/GYN Special Delivery.
Unlocking placenta accreta spectrum with single-cell gene targets
April 18th 2024Discover how cutting-edge single-cell RNA sequencing unveils molecular insights into placenta accreta spectrum disorders, potentially revolutionizing diagnostics and treatments for this life-threatening pregnancy complication.
Read More
Excessive gonadotropins in IVF: Effects on mosaicism and live birth
April 12th 2024A recent study revealed a correlation between high doses and prolonged duration of exogenous gonadotropin use during in vitro fertilization and increased embryonic mosaicism alongside diminished live birth rates, prompting reconsideration of dosage and duration protocols.
Read More
Dostarlimab shows significant survival benefits in endometrial cancer trial
March 21st 2024GlaxoSmithKline's phase 3 trial demonstrated promising overall and progression-free survival outcomes in patients with primary advanced or recurrent endometrial cancer, paving the way for potential FDA approval.
Read More