Asoprisnil: An alternative treatment for fibroids?

Article

Asoprisnil, a new selective progesterone receptor modulator, at a dosage of 25 mg daily for 12 weeks, suppressed uterine bleeding in 83% of women with uterine leiomyomata who took it and reduced leiomyoma volume by 36%, according to the results of a phase II trial.

Asoprisnil, a new selective progesterone receptor modulator, at a dosage of 25 mg daily for 12 weeks, suppressed uterine bleeding in 83% of women with uterine leiomyomata who took it and reduced leiomyoma volume by 36%, according to the results of a phase II trial.

The study involved 129 women from 28 sites in the US and one in Canada. The women were randomized to receive 5, 10, or 25 mg of oral asoprisnil or placebo daily for 3 months.

Asoprisnil suppressed uterine bleeding in 28%, 64%, and 83% of the women at 5, 10, and 25 mg, respectively. Only the 25-mg dosage, however, produced a statistically significant decrease in tumor volume at 4 and 8 weeks of treatment. The two highest dosages produced a significant reduction in bloating, and 25 mg produced a significant reduction in pelvic pressure by week 12.

Chwalisz K, Larsen L, Mattia-Goldberg C, et al. A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata. Fertil Steril. 2007;87:1399-1412.

Related Videos
Why doxycycline PEP lacks clinical data for STI prevention in women
The importance of nipocalimab’s FTD against FNAIT | Image Credit:  linkedin.com
Enhancing cervical cancer management with dual stain | Image Credit: linkedin.com
Fertility treatment challenges for Muslim women during fasting holidays | Image Credit: rmanetwork.com
Understanding the impact of STIs on young adults | Image Credit: providers.ucsd.edu.
CDC estimates of maternal mortality found overestimated | Image Credit: rwjms.rutgers.edu.
Study unveils maternal mortality tracking trends | Image Credit: obhg.com
How Harmonia Healthcare is revolutionizing hyperemesis gravidarum care | Image Credit: hyperemesis.org
Unveiling gender disparities in medicine | Image Credit:  findcare.ahn.org.
Exploring the intersection of heart health and women's health | Image Credit: cedars-sinai.org
© 2024 MJH Life Sciences

All rights reserved.