Benzodiazepines may influence cell growth and differentiation. This characteristic raises concerns about potential fetal abnormalities and miscarriages.
Research from the 1970s indicated that benzodiazepine consumption in early pregnancy might elevate the risk of birth defects, including facial anomalies and heart irregularities.2 However, subsequent studies did not consistently support these findings. They did, however, associate benzodiazepine usage with reduced birth weight and a heightened risk of ectopic pregnancies.3,4
A past study also explored the miscarriage risk, considering various factors.1 This research found that pregnant women taking benzodiazepines had an 85% higher likelihood of miscarriage. Notably, this study did not account for factors like anxiety severity, other health conditions, financial status, lifestyle, and genetics.
Lin-Chieh Meng, MS, and a team from the Graduate Institute of Clinical Pharmacy at National Taiwan University, conducted a fresh investigation to assess the miscarriage risk tied to benzodiazepine use during pregnancy. Their large-scale study included around 3 million pregnancies.
The study utilized two main data sources spanning several years. The National Health Insurance database, covering over 99% of Taiwan's population, identified miscarriages. Another database provided information on live births and stillbirths.
The study encompassed over 3 million pregnancies involving almost 2 million women. The average participant age was 30.61 years. Out of these, 4.4% experienced miscarriages. The team paired these cases with control subjects, ensuring similarity in age, health conditions, medication use, and healthcare interactions.
The study design allowed the researchers to address time-related factors and minimize biases. They observed that benzodiazepine exposure within specific periods correlated with increased miscarriage risks.
The researchers also examined different types of benzodiazepines. The results consistently pointed towards an increased miscarriage risk, even with variations in exposure assessment.
However, the study had limitations, such as reliance on prescription data and potential inaccuracies in abortion reporting. The researchers emphasized caution when prescribing benzodiazepines to pregnant women and stressed the importance of considering both the benefits and potential risks.
This article was written with the help of ChatGPT.
