Colorectal Ca outcomes improved with estrogen therapy for 5 years or less

Article

In women who are diagnosed with colorectal cancer, current use of postmenopausal estrogen therapy for 5 years or less is associated with significantly greater colorectal cancer-specific survival and overall survival, according to study findings published in the Dec. 20 issue of the Journal of Clinical Oncology.

In women who are diagnosed with colorectal cancer, current use of postmenopausal estrogen therapy for 5 years or less is associated with significantly greater colorectal cancer-specific survival and overall survival, according to study findings published in the Dec. 20 issue of the Journal of Clinical Oncology.

Jennifer A. Chan, MD, of the Dana-Farber Cancer Institute in Boston, and colleagues studied 834 women from the Nurses' Health Study who were diagnosed with colorectal cancer between 1976 and 2000.

The researchers found that women reporting current estrogen therapy before diagnosis had an adjusted hazard ratio of 0.64 for colorectal cancer-specific mortality and 0.74 for overall mortality compared to women reporting no previous estrogen use. But the survival benefit was most pronounced in those who reported current estrogen therapy for 5 years or less and was not significant in those who reported past or more prolonged use.

Chan JA, Meyerhardt JA, Chan AT, et al. Hormone replacement therapy and survival after colorectal cancer diagnosis. J Clin Oncol. 2006;24:5680-5686.

Recent Videos
Mitchell Creinin, MD, reports estetrol pill eases menstrual symptoms | Image Credit: health.ucdavis.edu
1 expert is featured in this series.
Susanna Mitro, PhD, reveals ethnic disparities in uterine fibroid diagnosis | Image Credit: divisionofresearch.kaiserpermanente.org.
Shayna Mancuso, DO, highlights the real impact of menopause | Image Credit: linkedin.com.
Jihong Liu, ScD, explains how to improve perinatal outcomes in COVID patients | Image Credit: sc.edu.
1 expert is featured in this series.
Jihong Liu, ScD, highlights adverse perinatal outcomes linked to the COVID pandemic | Image Credit: sc.edu.
Experts highlight infant health benefits from minor diet changes in pregnancy | Image Credit: ohsu.edu.
Connie Stark, RNC, PNC, provides fertility preservation insights for endometriosis patients | Image Credit: linkedin.com.
How the impact of maternal diet on infant health is strengthened in late pregnancy | Image Credit: ohsu.edu.
Related Content
© 2025 MJH Life Sciences

All rights reserved.