Contemporary OB/GYN week in review: Preeclampsia screening, BV treatment, and more

Thank you for visiting the Contemporary OB/GYN® website. Take a look at some of our top stories from last week (Monday, June 09, 2025 - Friday, June 13, 2025), and click each link to read and watch anything you may have missed.

Eran Bornstein, MD explains the need for first trimester preeclampsia screening

In a recent interview with Contemporary OB/GYN, Eran Bornstein, MD, director of obstetrics and gynecology at Northwell’s Lenox Hill Hospital, discussed the importance of early detection and targeted prevention strategies to reduce the risks associated with preeclampsia.

Preeclampsia is a serious pregnancy complication affecting 5% to 10% of pregnant women and is a major cause of maternal and fetal morbidity and mortality. A comprehensive first-trimester screening protocol offers the most effective method for identifying women at high risk of developing early preeclampsia, defined as occurring before 37 weeks of gestation.

This first-trimester screening includes a combination of maternal characteristics, biophysical markers, and serum biomarkers. When integrated, these factors create a highly individualized risk assessment.

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Secnidazole shows promise for recurrent BV treatment in new clinical trial

Further development of secnidazole oral granules (SOLOSEC; Evofem Biosciences, Inc.) for the treatment of bacterial vaginosis (BV) is supported by the results of a trial presented at the 2025 American College of Obstetricians and Gynecologists (ACOG) Annual Clinical and Scientific Meeting, according to Evofem Biosciences.

The trial included 24 women with recurrent BV. These participants received a 2g dose of secnidazole oral granules once per week, displaying similar or potentially improved efficacy results compared to suppressive treatments currently recommended by the Centers for Disease Control and Prevention (CDC).

"These study results demonstrate that 2 g oral secnidazole granules… effectively suppressed recurrence of BV with recurrence rates equivalent to and possibly better than published study outcomes of current CDC-recommended suppressive treatments,” said Chemen M. Neal, MD, associate clinical professor at the Indiana University School of Medicine and lead investigator.

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Similar IVF outcomes reported for PPOS and GnRH antagonist protocols

A gonadotropin-releasing hormone (GnRH) antagonist protocol and a progesterone-primed ovarian stimulation (PPOS) protocol lead to similar outcomes in ovarian stimulation, according to a recent study published in Cureus.

When stratifying by age, 10.9±5.6 oocytes were obtained in patients aged under 35 years in the GnRH antagonist cycle, vs 11.7±6.3 in the PPOS cycle. The number of blastocytes formed in this age group were 4.7 ± 5.4 vs 5.4 ± 3.1, respectively.

In patients aged 35 to 39 years, the number of oocytes obtained were 8.7 ± 7.4 vs 9.1 ± 5.4, respectively, while the number of blastocytes formed were 3.2 ± 3.5 vs 4.2 ± 3.3, respectively. Finally, the number of oocytes obtained were 6.4 ± 4.4 vs 7.6 ± 4.7, respectively, in those aged 40 years or older, while the number of blastocytes formed were 2.2 ± 0.4 vs 2.7 ± 2.3, respectively.

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Insulin resistance linked to abnormal uterine bleeding

There is a link between insulin resistance and abnormal uterine bleeding (AUB), according to a recent study published in Menopause, journal of The Menopause Society.

Approximately 30% of reproductive-aged women present with AUB, leading to over $34 billion in health care costs and significant adverse impacts on overall quality of life. This new data highlights shared risk factors of this condition with insulin resistance, indicating a potential link that may be used to improve prediction of AUB.

“These preliminary findings highlight the need for larger, longitudinal studies to confirm these relationships, identify causal mechanisms, and evaluate the potential of addressing hyperinsulinemia, being overweight, and obesity as part of prevention and treatment strategies for abnormal uterine bleeding,” said Stephanie Faubion, MD, MBA, medical director for The Menopause Society.

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FDA accepts NDA for zoliflodacin to treat gonorrhea

The FDA has accepted a New Drug Application (NDA) for zoliflodacin as a treatment against uncomplicated gonorrhea in patients aged at least 12 years, according to Innoviva Specialty Therapeutics, Inc.

This acceptance occurred following data from multiple clinical trials highlighting the efficacy of zoliflodacin as a single-dose treatment in pediatric and adult patients with uncomplicated gonorrhea. If approved, it will be the first new oral antibiotic for gonorrhea management in decades, according to the company.

“Today’s acceptance of the zoliflodacin NDA marks significant progress toward delivering health care providers with a potential new oral treatment option for uncomplicated gonorrhea, including infections caused by drug-resistant strains,” said David Altarac, MD, chief medical officer of Innoviva Specialty Therapeutics.

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