Cycle Syncing Method demonstrates reductions in premenstrual syndrome symptoms

Results from the first clinical study evaluating FLO Living’s Cycle Syncing Method revealed reductions in premenstrual syndrome (PMS) symptom burden and severity within 2 months, according to a March 10, 2026, news release from FLO Living.¹

Specifically, 92% of participants reported reductions in the number and intensity of PMS symptoms within 60 days, with some improvements occurring as early as 30 days. Results are based on an Institutional Review Board (IRB)-approved, 3-month study that provided a clinical validation for a diet and lifestyle approach to menstrual cycle health. By the end of the 3-month study period, other improvements such as reduced menstrual pain, blood sugar stability, better mood and energy, and increased cycle regularity were also observed.

"This study marks a turning point for women's hormonal health," said Alisa Vitti, founder of FLO Living and creator of the Cycle Syncing Method, in a press release. “For decades, women have been told that PMS is normal—or that medication is the only solution. These results show that when women align food, movement, and lifestyle choices with their menstrual cycle, real and measurable improvements can happen quickly, naturally, and without side effects."

The study was a virtual, single-group clinical trial that included 60 participants aged 22 to 42 years, of whom many had “long-standing menstrual symptoms such as painful cramps, heavy bleeding, headaches, bloating, acne, mood changes, fatigue, and sleep disruption,” according to FLO Living. Using the MyFLO app, study participants followed the Cycle Syncing Method every day, which provides phase-specific guidance for exercise type, nutrition, stress management, and scheduling aligned for the 4 phases of the menstrual cycle.

The study was done in conjunction with Mira’s at-home hormone tracking technology, Hello Inside’s continuous glucose monitoring and metabolic health insights, and Citruslabs’ IRB-approved research platform.

Key findings of Cycle Syncing Method included:

After 30 days:

• Eighty percent of participants reported fewer symptoms and reduced symptom severity.

After 60 days:

• 91.89% of participants reported reductions in both symptom burden and symptom intensity

After 90 days:

• 85.7% reduction in total reported symptoms
• 94.44% reported improved blood sugar stability
• 80.56% reported less painful periods
• Nearly 90% reported improved mood and energy
• 50% experienced more regular menstrual cycles

"Over 90% with fewer PMS symptoms. Nearly [9 in 10] satisfied with their hormonal health. And our glucose data confirmed what women were feeling was real—not imagined, but measurable,” said Mario Aichlseder, Hello Inside CEO and co-founder, in a statement. “That's the kind of evidence that changes what health care institutions are willing to fund."

Impacting approximately 80% of menstruating women, and with a global prevalence of 47.8%, PMS remains “one of the most under-researched and under-treated aspects of women's health,” according to FLO Living.^1,2

"This study provides evidence for a non-pharmaceutical option that works with women's biology rather than suppressing it," Vitti added. "It also reinforces the importance of the infradian rhythm—the monthly hormonal cycle unique to women—and the need for health strategies designed specifically around it."

References:

1. Cycle Syncing Method is clinically shown to reduce PMS symptoms for 92% of participants in 60 days. FLO Living. Press release. March 10, 2026. Accessed March 10, 2026. https://prnmedia.prnewswire.com/news-releases/cycle-syncing-method-is-clinically-shown-to-reduce-pms-symptoms-for-92-of-participants-in-60-days-302709427.html
2. Modzelewski S, Oracz A, Zukow X, et al. Premenstrual syndrome: new insights into etiology and review of treatment methods. Frontiers in Psychiatry. Published April 23, 2024. Accessed March 10, 2026. doi:10.3389/fpsyt.2024.1363875