Women who remain at risk for very preterm birth 7 or more days after an initial course of corticosteroids should receive repeat doses to reduce neonatal morbidity, according to the findings of a recent hospital-based, randomized, controlled trial.
Women who remain at risk for very preterm birth 7 or more days after an initial course of corticosteroids should receive repeat doses to reduce neonatal morbidity, according to the findings of a recent hospital-based, randomized, controlled trial.
Almost 1,000 women who remained at risk for preterm birth at less than 32 weeks' gestation 1 week or more after receiving an initial course of prenatal corticosteroids were randomly assigned to receive either a repeat intramuscular (11.4 mg) dose of betamethasone or saline placebo. This was repeated every week the women remained undelivered.
Compared with the placebo group, fewer babies in the corticosteroid group had respiratory distress syndrome (41% vs. 33%, RR 0.82, 95% CI; 0.71–0.95) or severe lung disease (20% vs. 12%; RR 0.60, 95% CI; 0.46–0.79). In addition, they required less oxygen therapy and mechanical ventilation.
The authors of the editorial also question the necessity of repeated weekly administration of corticosteroids in babies delivered after 34 weeks' gestation, as were nearly 35% of those in the study. They assert that the outcomes of these babies are more favorable whether they are given one dose or 10 of betamethasone. They suggest an alternative strategy of only giving a subsequent dose of corticosteroid when confronted with the necessity of delivery and then stalling uterine activity for 24 to 48 hours after corticosteroid administration.
Crowther CA, Haslam RR, Hiller JE, et al. Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial. Lancet. 2006;367:1913-1919.
Montan S, Arulkumaran S. Neonatal respiratory distress syndrome. Lancet. 2006;367:1878-1879.
Hormone therapy safety: Study finds potential benefits for senior women
April 24th 2024A recent large-scale study challenged age-related concerns, suggesting hormone therapy may offer safety and even benefits for menopausal women aged over 65 years, aligning with The Menopause Society's 2022 Position Statement.
Read More
Hyperoxygenation use not linked to neonatal outcomes
April 23rd 2024Recent research evaluated the impact of maternal hyperoxygenation on neonatal Apgar scores, revealing no significant enhancement in outcomes among women with pathologic fetal heart rate tracing and suggesting limited efficacy of hyperoxygenation therapy in this context.
Read More
Study finds antihypertensive treatment reduces uterine fibroids risk
April 23rd 2024A recent study revealed that patients with untreated or new-onset hypertension face elevated chances of uterine fibroid diagnosis, underscoring the potential of antihypertensive therapy in mitigating this risk among midlife individuals.
Read More