Does clomiphene in early pregnancy increase the risk of hypospadias?
Evidently not, according to a large, Danish, population-based, case–control study.
Evidently not, according to a large, Danish, population-based, case–control study.
Clomiphene, which is structurally related to diethylstilbestrol (DES), has been linked to urogenital anomalies and testicular cancer in males exposed in utero. In addition, hypospadias has been reported in boys born to women exposed to DES in utero.
But this latest study calculated an odds ratio of developing hypospadias after exposure to clomiphene of only 0.48 (95% CI; 0.15–1.54). Restricting exposure to clomiphene to the first trimester and up to 30 days prior to conception did not alter the result substantially.
Newsletter
Get the latest clinical updates, case studies, and expert commentary in obstetric and gynecologic care. Sign up now to stay informed.
Trimethoprim–sulfamethoxazole not found to increase infant birth weight in HIV cases
July 9th 2025A recent randomized trial found no significant improvement in birth weight or key birth outcomes from antenatal trimethoprim–sulfamethoxazole prophylaxis in human immunodeficiency virus-positive pregnant women.
Read More
