Don't reduce chemotherapy dose for obese women with ER-negative breast Ca

Article

It seems obese breast cancer patients are frequently underdosed when it comes to chemotherapy.

It seems obese breast cancer patients are frequently underdosed when it comes to chemotherapy.

Researchers reviewed data from four randomized trials of the International Breast Cancer Study Group assessing the use of adjuvant classical chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil in premenopausal women with node-positive breast cancer.

They found that 39% of obese women received less than 85% of the chemotherapy dose specified by the protocol versus 16% of women with normal or intermediate body mass index. While this didn't significantly compromise outcome in the women with estrogen-receptor (ER)–positive disease, reducing the dose of chemotherapy was associated with a significantly worse outcome in the obese women with ER-negative cancer in terms of disease-free survival (total population hazards ratio ≥ 85% vs. <85%, 0.68, 95% CI; 0.54–0.86, P=0.0013) and overall survival (0.72, 0.56-0.94, P=0.0142).

Related Videos
One year out: Fezolinetant displays patient satisfaction for managing hot flashes | Image Credit: sutterhealth.org
Addressing maternal health inequities: Insights from CDC's Wanda Barfield | Image Credit: cdc.gov
Addressing racial and ethnic disparities in brachial plexus birth Injury | Image Credit: shrinerschildrens.org
Innovations in prenatal care: Insights from ACOG 2024 | Image Credit:  uofmhealth.org.
Unlocking therapeutic strategies for menopausal cognitive decline | Image Credit: uclahealth.org.
Navigating menopause care: Expert insights from ACOG 2024 | Image Credit: mayo.edu.
raanan meyer, md
Related Content
© 2024 MJH Life Sciences

All rights reserved.