ERT doesn't increase risk of endometrial cancer recurrence

Article

In the largest randomized, controlled trial to date on the subject, researchers found that estrogen-only hormone replacement therapy (ERT) does not increase the risk of recurrence of endometrial cancer in women surgically treated for the condition.

Conducted over a 5-year period, the study included over 1,200 women who had hysterectomy and bilateral salpingo-oophorectomy for stage I or II endometrial cancer and who were experiencing symptoms of menopause; 618 women received ERT and 618 received placebo.

Both groups experienced few disease recurrences (1.9% on ERT, 1.6% on placebo) or endometrial cancer deaths (0.5% on ERT, 0.6% on placebo), and both groups had a low incidence of new cancer diagnoses of any type, including breast cancer. The survival rate for the study population was 96.6%.

Barakat RR, Bundy BN, Spirtos NM, et al. A prospective randomized double-blind trial of estrogen replacement therapy versus placebo in women with stage I or II endometrial cancer: a Gynecologic Oncology Group Study. Abstract 1.

Newsletter

Get the latest clinical updates, case studies, and expert commentary in obstetric and gynecologic care. Sign up now to stay informed.

Recent Videos
Neal Barnard, MD, FACC, highlights AMA's new breast cancer prevention guidelines | Image Credit: pcrm.org.
Zachary Wagner, PhD, discusses the harms of bias in reproductive care | Image Credit: ornsife.usc.edu.
Ciera Kirkpatrick, PhD, shows how TikTok is transforming cervical cancer awareness | Image Credit: linkedin.com.
Maria Gallo, PhD, discusses high attendance at crisis pregnancy centers | Image Credit: © x.com.
Related Content
© 2025 MJH Life Sciences

All rights reserved.