FAQs: ASCO guideline on fertility preservation in people with cancer
Clinicians are advised to discuss reproductive risks and fertility preservation options with all cancer patients prior to initiating therapy to maximize future reproductive potential.
The American Society of Clinical Oncology (ASCO) released an updated clinical practice guideline in March 2025, providing evidence-based recommendations for fertility preservation in adult and pediatric patients diagnosed with cancer. In February 2026, a synopsis was published on JAMA on February 26, 2026, highlighting the guideline that incorporated data from 166 studies published between 2013 and 2024, from systematic reviews and randomized clinical trials. The guidance addresses the critical need for early intervention, as cancer treatments often carry gonadotoxic potential that can permanently impair reproductive function.1,2