HPV test more effective than traditional Pap, but there's a caveat

Article

A test for oncogenic HPV alone or combined with a conventional Pap smear can detect cervical intraepithelial neoplasia with a higher sensitivity than the Pap smear alone.

A test for oncogenic human papillomavirus (HPV) alone or combined with a conventional Pap smear can detect cervical intraepithelial neoplasia with a higher sensitivity than the Pap smear alone, according to two studies published in the Oct. 18 issue of the New England Journal of Medicine.

In the first study, Marie-Helene Mayrand, MD, from McGill University in Montreal, Canada, and colleagues performed HPV testing and conventional Pap testing in 10,154 women (aged 30 to 69 years) to identify high-grade cervical intraepithelial neoplasia. They found that HPV testing had a sensitivity of 94.6% compared with 55.4% for Pap testing and a specificity of 94.1% compared with 96.8% for Pap testing.

In the second study, Pontus Naucler, MD, PhD, from Lund University in Malmo, Sweden, and colleagues randomly assigned 12,527 women (aged 32 to 38 years) to either an HPV test plus a Pap test or a Pap test alone. They found that 51% more women receiving both tests were found to have high-grade cervical intraepithelial neoplasia or cancer. At later screening tests, women receiving both tests had 42% lower rates of high-grade intraepithelial neoplasia or cancer, suggesting that the addition of the HPV test reduced the incidence of cervical cancer.

Mayrand MH, Duarte-Franco E, Rodrigues I, et al. Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer. N Engl J Med. 2007;357:1579-1588.

Naucler P, Ryd W, Törnberg S, et al. Human papillomavirus and Papanicolaou tests to screen for cervical cancer. N Engl J Med. 2007;357:1589-1597.

Related Videos
Why doxycycline PEP lacks clinical data for STI prevention in women
The importance of nipocalimab’s FTD against FNAIT | Image Credit:  linkedin.com
Enhancing cervical cancer management with dual stain | Image Credit: linkedin.com
Fertility treatment challenges for Muslim women during fasting holidays | Image Credit: rmanetwork.com
Understanding the impact of STIs on young adults | Image Credit: providers.ucsd.edu.
CDC estimates of maternal mortality found overestimated | Image Credit: rwjms.rutgers.edu.
Study unveils maternal mortality tracking trends | Image Credit: obhg.com
How Harmonia Healthcare is revolutionizing hyperemesis gravidarum care | Image Credit: hyperemesis.org
Unveiling gender disparities in medicine | Image Credit:  findcare.ahn.org.
Exploring the intersection of heart health and women's health | Image Credit: cedars-sinai.org
© 2024 MJH Life Sciences

All rights reserved.