Postmenopausal women receiving hormone therapy reduce their risk of developing colorectal cancer by more than half, according to a study published online Aug. 24 in the Journal of Clinical Oncology.
Postmenopausal women receiving hormone therapy reduce their risk of developing colorectal cancer by more than half, according to a study published online Aug. 24 in the Journal of Clinical Oncology.
Gad Rennert, MD, from the Carmel Medical Center in Haifa, Israel, and colleagues compared the self-reported use of HRT from 2,460 peri- and postmenopausal women among 2,648 patients with colorectal cancer and 2,566 controls.
After adjusting for demographics, aspirin and statin use, sports activity, family history of colorectal cancer, and vegetable consumption, the researchers found that women reporting HRT use had a significantly lower risk of colorectal cancer (OR, 0.37). Women who took aspirin or played sports did not have a risk reduction. The reduced risk was observed mainly in women taking combined estrogen-progestin oral pills.
“The use of oral HRT was associated with a 63% relative reduction in the risk of colorectal cancer in postmenopausal women after adjustment for other known risk factors,” Rennert and colleagues conclude. “However, the absence of the risk reduction effect of aspirin in HRT users and the differences in risk reduction with preparation-type call for further study to understand the causes for these phenomena and calls for caution in indicating HRT for colorectal cancer prevention.”
Rennert G, Rennert HS, Pinchev M, et al. Use of Hormone Replacement Therapy and the Risk of Colorectal Cancer. J Clin Oncol. 2009 Aug 24.
Personalized opioid protocol for cesarean deliveries: Reduced prescriptions reported
April 19th 2024A recent suggests that implementing a personalized opioid prescription protocol significantly reduces total morphine milligram equivalents and the number of opioid tablets prescribed at discharge following cesarean delivery.
Read More
Gender discrepancy found in ABCA4-associated retinopathy
April 18th 2024A recent meta-analysis suggests sex as a modifying factor in the development of ABCA4-associated retinopathy, revealing a higher proportion of women among individuals with a mild reduced penetrant ABCA4 variant, impacting prognosis predictions and recurrence risks.
Read More
Genetics associated with reproductive traits and uterine leiomyomata
April 17th 2024Investigating genetic correlations and shared loci sheds light on potential causal relationships between reproductive traits and uterine leiomyomata, offering insights into their complex interplay and urging further mechanistic exploration.
Read More