Dr. John Collins presented a thorough review of the literature concerning the interaction of hormone replacement and breast cancer entitled "HRT and Breast Cancer: The Evidence and the Issues" with the following general conclusions
Dr. John Collins presented a thorough review of the literature concerning the interaction of hormone replacement and breast cancer entitled "HRT and Breast Cancer: The Evidence and the Issues" with the following general conclusions:
Differences in Risk
The increased risk of each year of hormone replacement therapy (HRT) is 1.023, and the increased risk of each year of delayed menopause is 1.028, thus it appears there is essentially no difference in a year of hormone replacement or a year's delay in experiencing menopause.
Comparison of estrogen alone or estrogen and progesterone showed no significantly increased risk with less than 5 years of replacement, and an increased risk of over 5 years of HRT.
There is a trend of an increased risk with the addition of progesterone over that of estrogen alone, but the database is still too small.
There was no difference in risk between HRT with conjugated estrogens or estradiol.
There was no increased risk with increases in dosages of HRT.
There is no difference in the increase of risk in a woman with a positive family history over that of one with a negative family history (no exaggerated risk).
The increased risk of breast cancer with HRT is actually less than that of a woman who consumes over two drinks of an alcoholic beverage per day.
Low creatinine-to-cystatin C ratio linked to postmenopausal muscle loss
March 20th 2025A new study finds that postmenopausal women with a reduced creatinine-to-cystatin C ratio experience decreased muscle volume and slower walking speed, highlighting its role as a potential biomarker for muscle health.
Read More
Intentional weight loss linked to lower mortality in postmenopausal women
March 11th 2025A recent study shows that intentional weight loss significantly lowers all-cause, cancer, and cardiovascular mortality risks among postmenopausal women, highlighting the importance of targeted weight management.
Read More