According to a recent study published in Reproductive Biology and Endocrinology, inositol is safe and effective against polycystic ovary syndrome (PCOS).
Takeaways
- Inositol is a safe and effective treatment for polycystic ovary syndrome (PCOS), a common endocrine disorder and a leading cause of infertility in women.
- PCOS is often associated with insulin resistance, and inositols, a group of compounds in the vitamin B complex, have been found to improve menstrual cycle regularity, carbohydrate metabolism, and symptoms of hyperandrogenism in women with PCOS.
- A systematic review and meta-analysis of 26 randomized controlled trials involving 1691 women with PCOS demonstrated that inositol significantly increased menstrual cycle normalization compared to placebo.
- Inositol also led to a reduction in body mass index, especially when myoinositol was used, and a decrease in total testosterone levels and fasting plasma glucose levels.
- While inositol did not significantly impact pregnancy rates, it was associated with fewer adverse events compared to metformin, a commonly used medication for PCOS. The study suggests that inositol should be considered as part of the treatment guidelines for PCOS.
PCOS is reported in 5% to 20% of reproductive aged women, making it the most common endocrine disorder and one of the most common causes of infertility in women. It is diagnosed if 2 of the 3 criteria are met: hyperandrogenism, ovulatory dysfunction, and polycystic ovary morphology.
While the pathogenesis of PCOS is not fully understood, insulin resistance (IR) is vital to its pathogenesis. Data has indicated IR in 75% of lean and 95% of overweight women with PCOS, with 60% to 70% of women with PCOS being overweight and IR being more severe in obese women.
Inositols, insulin sensitizers in the vitamin B complex group, have positive effects on menstrual cycle regularity, carbohydrate metabolism, and laboratory and clinicalsymptoms of hyperandrogenism. However, evidence supporting inositol for treating PCOS is lacking.
To determine the safety and efficacy of inositol against PCOS, investigators conducted a systematic review and meta-analysis. Menstrual cycle normalization was measured as the primary outcome of the analysis. Secondary outcomes included pregnancy rate, body mass index (BMI), carbohydrate metabolism, clinical and laboratory hyperandrogenism, and treatment side effects.
Eligibility criteria for randomized controlled trials (RCTs) included comparing the safety and efficacy of inositols vs placebo or metformin in women with PCOS, diagnosing PCOS based on Rotterdam or corresponding criteria, and having monotherapy inositol or inositol in combination with dietary supplements or aromatase inhibitors as the primary intervention.
RCTs were found through searches of MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases through October 20th, 2021. Articles were extracted by 2 independent reviewers, with screening being initially based on the title and abstract, then the full text through eligibility criteria.
Data extracted included title, first author, year of publication, countries, number of centers, study design, main study findings, patient demographics, inclusion and exclusion criteria, details regarding the population, intervention, comparator, and outcome, and event rates.
