Menopause: not just ovarian failure

Article

Menopause is not simply the result of ovarian failure or depletion; evidently it's also the result of a hypothalamic-pituitary insensitivity to estrogen during the perimenopausal period, according to a multiethnic, observational, cohort study.

Menopause is not simply the result of ovarian failure or depletion; evidently it's also the result of a hypothalamic-pituitary insensitivity to estrogen during the perimenopausal period, according to a multiethnic, observational, cohort study.

To reach that conclusion, researchers reviewed the daily urinary hormone levels of estrogen and progesterone metabolites, LH, and FSH of 160 women without luteal activity, categorizing them into three groups: those with estrogen increases with an LH surge, those with estrogen increases without an LH surge, and those with neither.

Women with low estrogen levels and an LH surge experienced more hot flashes than women in either of the other two groups. The authors reported that older reproductive-aged women frequently have anovulatory cycles with estrogen peaks that are equivalent to those resulting in LH surges in younger women, but no LH surges occur, indicating a lack of estrogen-positive feedback on the hypothalamus, which would normally stimulate the pituitary to secrete LH. In other anovulatory cycles, follicular-phase estrogen levels failed to lower LH secretion as occurs in younger women, indicating decreased estrogen-negative feedback on LH secretion.

Weiss G, Skurnick JH, Goldsmith LT, et al. Menopause and hypothalamic-pituitary sensitivity to estrogen. JAMA. 2004;292:2991-2996.

Related Videos
One year out: Fezolinetant displays patient satisfaction for managing hot flashes | Image Credit: sutterhealth.org
Addressing maternal health inequities: Insights from CDC's Wanda Barfield | Image Credit: cdc.gov
Addressing racial and ethnic disparities in brachial plexus birth Injury | Image Credit: shrinerschildrens.org
Innovations in prenatal care: Insights from ACOG 2024 | Image Credit:  uofmhealth.org.
Unlocking therapeutic strategies for menopausal cognitive decline | Image Credit: uclahealth.org.
Navigating menopause care: Expert insights from ACOG 2024 | Image Credit: mayo.edu.
raanan meyer, md
New data shows elinzanetant's efficacy in treating menopausal symptoms | Image Credit: uvahealth.com
Related Content
© 2024 MJH Life Sciences

All rights reserved.