News: Daidzein-rich isoflavones reduce menopausal hot flashes


Daidzein-rich isoflavones improve hot flash frequency and severity.

Daidzein-rich isoflavone aglycones (DRIs), 40 or 60 mg a day, improved hot flash frequency and severity by about 40% after 8 weeks of treatment and by about 50% after 12 weeks, without causing any significant changes in endogenous sex or thyroid hormones.

The findings come from a randomized, double-blind, placebo-controlled trial involving approximately 150 menopausal women between the ages of 38 and 60 years. The two active groups were given an isoflavone-rich supplement made from soy germ. The researchers calculated that 40- and 60-mg DRIs reduced hot flash frequency by 43% and 41%, respectively, at 8 weeks versus 32% for placebo (P not significant). At 12 weeks, the reductions were 52%, 51%, and 39% for 40-mg DRIs, 60-mg DRIs, and placebo, respectively (P=.07 and .09 vs. placebo).

Reports about isoflavones effectively treating menopausal symptoms have been conflicting. Reasons for the inconsistencies may include differences in methods used to isolate isoflavones, concentrations of bioavailable isoflavones, or the composition of isoflavones used. Since no studies have reported harmful effects of isoflavones on menopausal symptoms, they may represent an alternative or adjunct to hormone therapy.

Related Videos
Why doxycycline PEP lacks clinical data for STI prevention in women
The importance of nipocalimab’s FTD against FNAIT | Image Credit:
Enhancing cervical cancer management with dual stain | Image Credit:
Fertility treatment challenges for Muslim women during fasting holidays | Image Credit:
Understanding the impact of STIs on young adults | Image Credit:
CDC estimates of maternal mortality found overestimated | Image Credit:
Study unveils maternal mortality tracking trends | Image Credit:
How Harmonia Healthcare is revolutionizing hyperemesis gravidarum care | Image Credit:
Unveiling gender disparities in medicine | Image Credit:
Exploring the intersection of heart health and women's health | Image Credit:
Related Content
© 2024 MJH Life Sciences

All rights reserved.