Postmenopausal hormone therapy cuts lung cancer risk

Article

Postmenopausal women who've taken hormone therapy have a lower risk of non-small-cell lung cancer (NSCLC) and particularly estrogen receptor-positive tumors.

Postmenopausal women who've taken hormone therapy have a lower risk of non-small-cell lung cancer (NSCLC) and particularly estrogen receptor-positive tumors, according to a study published in the Dec. 20 issue of the Journal of Clinical Oncology.

Ann G. Schwartz, PhD, of the Karmanos Cancer Institute in Detroit, and colleagues conducted a study of women aged 18 to 74 years comprising 488 NSCLC patients, of whom 241 had tumor estrogen-receptor results, and 498 controls.

The researchers found that the longer postmenopausal women were on HT, the lower their odds of developing lung cancer. The inverse association was found most strongly for estrogen receptor-positive NSCLC. None of the study's hormone variables were found to be associated with estrogen receptor-negative NSCLC tumors.

Schwartz AG, Wenzlaff AS, Prysak GM et al. Reproductive factors, hormone use, estrogen receptor expression and risk of non–small-cell lung cancer in women. J Clin Oncol. 2007;25:5785-5792.

Recent Videos
First US national HPV conference highlights advances in cancer prevention | Image Credit: uchealth.com.
Mitchell Creinin, MD, reports estetrol pill eases menstrual symptoms | Image Credit: health.ucdavis.edu
1 expert is featured in this series.
Susanna Mitro, PhD, reveals ethnic disparities in uterine fibroid diagnosis | Image Credit: divisionofresearch.kaiserpermanente.org.
Shayna Mancuso, DO, highlights the real impact of menopause | Image Credit: linkedin.com.
Jihong Liu, ScD, explains how to improve perinatal outcomes in COVID patients | Image Credit: sc.edu.
1 expert is featured in this series.
Jihong Liu, ScD, highlights adverse perinatal outcomes linked to the COVID pandemic | Image Credit: sc.edu.
Experts highlight infant health benefits from minor diet changes in pregnancy | Image Credit: ohsu.edu.
Connie Stark, RNC, PNC, provides fertility preservation insights for endometriosis patients | Image Credit: linkedin.com.
Related Content
© 2025 MJH Life Sciences

All rights reserved.