Preventing pregnancy loss with aspirin and low-molecular-weight heparin

July 1, 2005

Low-dose aspirin combined with low-molecular-weight heparin (LMWH) during pregnancy is just as safe and effective as aspirin with unfractionated heparin (UFH) for preventing recurrent pregnancy loss due to antiphospholipid syndrome, according to a prospective, controlled, multicenter pilot study.

Low-dose aspirin combined with low-molecular-weight heparin (LMWH) during pregnancy is just as safe and effective as aspirin with unfractionated heparin (UFH) for preventing recurrent pregnancy loss due to antiphospholipid syndrome, according to a prospective, controlled, multicenter pilot study.

The study included 50 women. Of 25 who received LMWH, 21 (84%) delivered a viable infant and 4 (16%) miscarried. Among 25 who received UFH, 20 (80%) delivered a viable infant and five (20%) miscarried. The differences were not statistically significant. No major bleeding episodes occurred during pregnancy or birth, and no cases of deep venous thrombosis, thrombocytopenia, preeclampsia, gestational diabetes, or bone fractures occurred in either group.

The investigators concluded that a large, randomized trial is now needed to further determine any differences in outcomes.