Recombinant activated factor VII (rFVIIa) improves severe primary postpartum hemorrhage in 80% of women in whom it is used as treatment-in many cases after a single dose-and in 75% of women in whom it is used as prophylaxis, with few adverse effects, according to findings from the Northern European Registry. Four cases of thromboembolism, one myocardial infarction, and one skin rash occurred as a result of rFVIIa administration.
Recombinant activated factor VII (rFVIIa) improves severe primary postpartum hemorrhage in 80% of women in whom it is used as treatment-in many cases after a single dose-and in 75% of women in whom it is used as prophylaxis, with few adverse effects, according to findings from the Northern European Registry. Four cases of thromboembolism, one myocardial infarction, and one skin rash occurred as a result of rFVIIa administration.
Researchers collected data on women with obstetric hemorrhage between the years 2000 to 2004 from nine European countries. Most of the cases were of a sort in which all other conventional measures were failing. In fact, rFVIIa treatment failed, too, in 15 cases (13.8%). Even with the treatment, 82 women were admitted to intensive care units, five of 113 women died, and about half required laparotomy (including hysterectomy in 33 cases).
While the authors of the review were careful not to comment on the true efficacy of rFVIIa without an adequate control group, the agent seems to provide significant benefit for a lot of women.
Alfirevic Z, Elbourne D, Pavord S, et al. Use of recombinant activated factor VII in primary postpartum hemorrhage: the Northern European Registry 2000-2004. Obstet Gynecol. 2007;110:1270-1278.
Commentary from Sharon T. Phelan, MD, Professor, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM.
Life-threatening postpartum hemorrhage that does not respond to typical medical or surgical intervention is uncommon, but can be deadly. The off-label use of activated factor VII has been recommended with little data to support it, but a randomized study is clearly not an option. This international summary provides more support as to the role of this intervention to deal with peripartum hemorrhage, which in turn may save lives and prevent peripartum hysterectomies.
SART data indicates rise in IVF use in 2022
April 24th 2024Dive into the latest statistics from the Society for Assisted Reproductive Technology, revealing a 6% increase in in vitro fertilization cycles and a surge in egg freezing, amidst a landscape of rising fertility service demand and evolving clinical practices.
Read More
Hormone therapy safety: Study finds potential benefits for senior women
April 24th 2024A recent large-scale study challenged age-related concerns, suggesting hormone therapy may offer safety and even benefits for menopausal women aged over 65 years, aligning with The Menopause Society's 2022 Position Statement.
Read More