Higher total and free estradiol levels in the early follicular phase of the menstrual cycle, and higher total and free testosterone levels in the early follicular and midluteal phases increase a premenopausal woman's risk of breast cancer, according to a prospective case–control study of over 18,000 premenopausal women nested within the Nurses' Health Study II.
Higher total and free estradiol levels in the early follicular phase of the menstrual cycle, and higher total and free testosterone levels in the early follicular and midluteal phases increase a premenopausal woman's risk of breast cancer, according to a prospective case–control study of over 18,000 premenopausal women nested within the Nurses' Health Study II.
While experts have known that higher levels of endogenous sex steroid hormones increase the risk of breast cancer in postmenopausal women, an association in younger women has been difficult to demonstrate because hormone levels vary cyclically.
But researchers found that women in the highest quartiles of follicular total and free estradiol levels had approximately twice the risk of breast cancer as women in the lowest quartiles, with the strongest associations for invasive disease and for estrogen and progesterone receptor-positive (ER+/PR+) tumors. Similarly, women with the highest levels of total and free testosterone and androstenedione in both the early follicular and midluteal phases of the menstrual cycle were twice as likely to develop invasive disease as women with the lowest amounts and about three times as likely to develop ER+/PR+ cancers.
Unraveling preeclampsia: Insights into heterogeneity and intravascular inflammation
April 22nd 2024A recent study delved into the intricate clusters of term preeclampsia, shedding light on its diverse manifestations and the pivotal role of intravascular inflammation, paving the way for improved classification and management strategies.
Read More
Personalized opioid protocol for cesarean deliveries: Reduced prescriptions reported
April 19th 2024A recent suggests that implementing a personalized opioid prescription protocol significantly reduces total morphine milligram equivalents and the number of opioid tablets prescribed at discharge following cesarean delivery.
Read More
Long-term mortality risks for women with adverse pregnancy outcomes
April 19th 2024A recent study revealed that women who experience major adverse pregnancy outcomes face heightened long-term mortality risks, shedding light on the need for comprehensive understanding and preventative measures in women's health.
Read More