Sex steroids and breast density predict breast cancer risk

Article

Both circulating sex steroid levels and mammographic density are strong and independent predictors of breast Ca risk in postmenopausal women. . .

Both circulating sex steroid levels and mammographic density are strong and independent predictors of breast cancer risk in postmenopausal women, according to the results of a nested case-control study.

Using a cohort of 253 women with breast cancer and 520 controls within the Nurses' Health Study, researchers found that women in the highest quartile for mammographic density had almost four times the risk for breast cancer as women in the lowest quartile (RR 3.8; 95% CI, 2.2–6.6; Ptrend<0.001). Adjusting the analysis for circulating estradiol or circulating testosterone made little change (RR 3.9; 95% CI, 2.2–6.0; Ptrend<0.001; and RR 4.1; 95% CI, 2.3–7.2, Ptrend<0.001, respectively). Women with high levels of circulating estradiol or circulating testosterone had about twice as high a risk for developing breast cancer as women with low levels, before and after adjustment for mammographic density (RR 2.4; 95% CI, 1.4–4.0; and RR 2.0; 95% CI, 1.2–3.1, respectively). Women who had both high levels of plasma testosterone and very dense breasts were at six times the risk for breast cancer as women in the lowest tertiles for both (RR 6.0; 95% CI, 2.6–14.0). Figures were similar for women with both high circulating estradiol and mammographic density (RR 4.1; 95% CI, 1.7–9.8).

Tamimi RM, Byrne C, Colditz GA, et al. Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 2007;99:1178-1187.

Related Videos
Why doxycycline PEP lacks clinical data for STI prevention in women
The importance of nipocalimab’s FTD against FNAIT | Image Credit:  linkedin.com
Enhancing cervical cancer management with dual stain | Image Credit: linkedin.com
Fertility treatment challenges for Muslim women during fasting holidays | Image Credit: rmanetwork.com
Understanding the impact of STIs on young adults | Image Credit: providers.ucsd.edu.
CDC estimates of maternal mortality found overestimated | Image Credit: rwjms.rutgers.edu.
Study unveils maternal mortality tracking trends | Image Credit: obhg.com
How Harmonia Healthcare is revolutionizing hyperemesis gravidarum care | Image Credit: hyperemesis.org
Unveiling gender disparities in medicine | Image Credit:  findcare.ahn.org.
Exploring the intersection of heart health and women's health | Image Credit: cedars-sinai.org
Related Content
© 2024 MJH Life Sciences

All rights reserved.