Teriparatide more effective than alendronate for drug-induced osteoporosis

Article

Teriparatide, a recombinant human parathyroid hormone, is more effective than alendronate, a bisphosphonate, in improving bone mineral density and reducing fractures in patients with glucocorticoid-induced osteoporosis.

Teriparatide, a recombinant human parathyroid hormone, is more effective than alendronate, a bisphosphonate, in improving bone mineral density (BMD) and reducing fractures in patients with glucocorticoid-induced osteoporosis, according to a report in the Nov. 15 issue of the New England Journal of Medicine.

Kenneth G. Saag, MD, from the University of Alabama at Birmingham, and colleagues randomly assigned 428 men and women with osteoporosis who had received glucocorticoids for at least 3 months to either 20 μg teriparatide or 10 mg alendronate once a day for 18 months.

The researchers found that mean BMD at the lumbar spine increased significantly more in the teriparatide group (7.2%) versus the alendronate group (3.4%), which was evident after 6 months. The mean BMD in the hip also increased significantly more in patients treated with teriparatide, which was evident after 12 months. The teriparatide group had significantly fewer new vertebral fractures (0.6% vs. 6.1%) and at least one elevated measure of serum calcium.

Saag KG, Shane E, Boonen S, et al. Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N Engl J Med. 2007;357:2028-2039.

Related Videos
Why doxycycline PEP lacks clinical data for STI prevention in women
The importance of nipocalimab’s FTD against FNAIT | Image Credit:  linkedin.com
Enhancing cervical cancer management with dual stain | Image Credit: linkedin.com
Fertility treatment challenges for Muslim women during fasting holidays | Image Credit: rmanetwork.com
Understanding the impact of STIs on young adults | Image Credit: providers.ucsd.edu.
CDC estimates of maternal mortality found overestimated | Image Credit: rwjms.rutgers.edu.
Study unveils maternal mortality tracking trends | Image Credit: obhg.com
How Harmonia Healthcare is revolutionizing hyperemesis gravidarum care | Image Credit: hyperemesis.org
Unveiling gender disparities in medicine | Image Credit:  findcare.ahn.org.
Exploring the intersection of heart health and women's health | Image Credit: cedars-sinai.org
Related Content
© 2024 MJH Life Sciences

All rights reserved.