Trastuzumab may cause cardiac toxicity, but effects are usually reversible

Article

In women with HER2-positive metastatic breast cancer, trastuzumab can cause cardiac toxicity, which can be reversed with beta-blockers and ACE inhibitors. Additional trastuzumab treatment can be considered after recovery of cardiac function, according to a study published online August 14 in the Journal of Clinical Oncology.

In women with HER2-positive metastatic breast cancer, trastuzumab can cause cardiac toxicity, which can be reversed with beta-blockers and ACE inhibitors. Additional trastuzumab treatment can be considered after recovery of cardiac function, according to a study published online August 14 in the Journal of Clinical Oncology.

Valentina Guarneri, MD, of the University of Texas M.D. Anderson Cancer Center in Houston, and colleagues studied 218 patients who received trastuzumab for a median of 21.3 months.

The researchers found that 49 of the patients (28%) experienced cardiac events. Of these, three (1.7%) had an asymptomatic 20% decrease in left ventricular ejection fraction (LVEF), 27 (15.6%) experienced grade 2 cardiac toxicity, 19 (10.9%) experienced grade 3 cardiac toxicity, and one (0.5%) died of cardiac causes. The investigators found that all but three of the surviving patients improved when trastuzumab was discontinued and appropriate therapy was started.

Guarneri V, Lenihan DJ, Valero V, et al. Long-Term Cardiac Tolerability of Trastuzumab in Metastatic Breast Cancer: The M.D. Anderson Cancer Center Experience. J Clin Oncol. (Published online August 14, 2006. at http:// http://www.jco.org/cgi/content/abstract/JCO.2005.04.9551v1.)

Related Videos
Why doxycycline PEP lacks clinical data for STI prevention in women
The importance of nipocalimab’s FTD against FNAIT | Image Credit:  linkedin.com
Enhancing cervical cancer management with dual stain | Image Credit: linkedin.com
Fertility treatment challenges for Muslim women during fasting holidays | Image Credit: rmanetwork.com
Understanding the impact of STIs on young adults | Image Credit: providers.ucsd.edu.
CDC estimates of maternal mortality found overestimated | Image Credit: rwjms.rutgers.edu.
Study unveils maternal mortality tracking trends | Image Credit: obhg.com
How Harmonia Healthcare is revolutionizing hyperemesis gravidarum care | Image Credit: hyperemesis.org
Unveiling gender disparities in medicine | Image Credit:  findcare.ahn.org.
Exploring the intersection of heart health and women's health | Image Credit: cedars-sinai.org
Related Content
© 2024 MJH Life Sciences

All rights reserved.