British investigators argue that many of the studies supporting drug treatment of osteopenia understate the side effects, overstate the benefits, involve potential conflicts of interest, and base efficacy claims on reductions in relative, rather than absolute, risk for fractures.
British investigators argue that many of the studies supporting drug treatment of osteopenia understate the side effects, overstate the benefits, involve potential conflicts of interest, and base efficacy claims on reductions in relative, rather than absolute, risk for fractures.
They cite one raloxifene trial that touts a 75% reduction in relative risk of fracture, which translates into only a 0.9% reduction in absolute risk. They also mention four studies, one each involving alendronate, raloxifene, risedronate, and strontium ranelate, that indicate anywhere from 0.9% to 8.6% absolute risk exists over 3 to 5 years in control patients. That means that anywhere from 133 to 270 women with preosteoporosis (women "at risk for being at risk") need to be treated with drugs for 3 years to prevent a single fracture in one of them.
The World Health Organization is currently developing an absolute fracture risk algorithm to assist practitioners with managing women categorized as having osteopenia. In the meantime, the practitioners remind us that the number 1 risk factor for fracture is falls, not low bone mineral density, and that we should work on preventing the former as much as we do the latter.
Get the latest clinical updates, case studies, and expert commentary in obstetric and gynecologic care. Sign up now to stay informed.
Study finds pregnancy risks higher with ART in kidney transplant recipients
July 11th 2025Women with kidney transplants who conceive through assisted reproductive technology face increased risks of complications such as hypertension, preterm birth, and cesarean delivery, according to new research.
Read More