Adding hyperthermia to standard chemoradiotherapy for advanced cervical carcinoma seems to boost the positive effects of treatment without adding any negative effects, according to analysis of three phase 2 studies.  

Most of 68 women with a median age of 45 years and stage IIB, III, or IVA disease received a biologically effective radiotherapy and brachytherapy dose of 86.7 gray or higher, at least four courses of 40 mg/m2 weekly cisplatin, and four weekly sessions of locoregional hyperthermia.  

Ninety percent of the women achieved complete remission. After a median of 18 months, 84% of the women remained alive, 74% of whom were without recurrence. Toxicity was comparable to that with chemoradiotherapy alone. A phase 3 study of the triple treatment is underway.  

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Adding hyperthermia to standard chemoradiotherapy for advanced cervical carcinoma seems to boost the positive effects of treatment without adding any negative effects, according to analysis of three phase 2 studies.