vAF glucose highly predictive of, but not sensitive for, infection

Article

A low (<5 mg/dL) vaginal amniotic fluid (vAF) glucosemeasurement can predict the presence of intra-amniotic infection(IAI), and rule it out, but has a low sensitivity for thecondition.

A low (<5 mg/dL) vaginal amniotic fluid (vAF) glucose measurement can predict the presence of intra-amniotic infection (IAI), and rule it out, but has a low sensitivity for the condition.

Researchers at Yale University retrieved amniotic fluid via transabdominal amniocentesis (aAF) from 35 consecutive women with preterm premature rupture of membranes (PPROM) and compared it with vaginal pool samples.

They found substantial agreement between aAF and vAF glucose concentrations, and that women with IAI had significantly lower aAF and vAF glucose levels than noninfected women. They calculated that a vaginal pool glucose measurement of less than 5 mg/dL had 47.1% sensitivity, 100% specificity, and 100% positive predictive value in identifying women with positive microbial cultures in their amniotic fluid.

Buhimschi CS, Sfakianaki AK, Hamar BG, et al. A low vaginal "pool" amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes. Am J Obstet Gynecol. 2006;194:309-316.

Recent Videos
Elizabeth Gandee, APRN-CNP, highlights gaps in women's menopause knowledge | Image Credit: wexnermedical.osu.edu
Doula highlights how postpartum care is failing new mothers | Image Credit: linkedin.com
Nicky Herrick MD; and Anushree Agarwal, MD, MBBS, highlight their study on cardiac arrhythmias in pregnancy | Image Credit: © Igor Borodin - stock.adobe.com.
Lisa Becht, MD, FACOG, sheds light on fertility awareness | Image Credit: havingbabies.com.
First US national HPV conference highlights advances in cancer prevention | Image Credit: uchealth.com.
Mitchell Creinin, MD, reports estetrol pill eases menstrual symptoms | Image Credit: health.ucdavis.edu
1 expert is featured in this series.
Susanna Mitro, PhD, reveals ethnic disparities in uterine fibroid diagnosis | Image Credit: divisionofresearch.kaiserpermanente.org.
Shayna Mancuso, DO, highlights the real impact of menopause | Image Credit: linkedin.com.
Jihong Liu, ScD, explains how to improve perinatal outcomes in COVID patients | Image Credit: sc.edu.
Related Content
© 2025 MJH Life Sciences

All rights reserved.