Vaginal progesterone gel may be preferable for luteal phase support

February 1, 2005

Vaginally applied progesterone gel provides higher endometrial levels and lower systemic levels of progesterone than intramuscularly administered progesterone, according to a prospective, randomized study involving 32 postmenopausal women. All of the participants used transdermal estradiol (50 ?g/day, a patch each week) for 2 weeks. In addition, they used 50 mg of either vaginal progesterone gel or IM progesterone in oil after 24 hours to oppose the transdermal estradiol.