Infants exposed to HIV in the womb, but not infected at birth, have lower infant-specific antibody responses against some diseases, compared to infants not exposed to HIV, according to a study published in the Feb. 8 issue of the Journal of the American Medical Association
TUESDAY, Feb. 8 (HealthDay News) -- Infants exposed to HIV in the womb, but not infected at birth, have lower infant-specific antibody responses against some diseases, compared to infants not exposed to HIV, according to a study published in the Feb. 9 issue of the Journal of the American Medical Association.
Christine E. Jones, B.M.B.S., of the Imperial College London, and colleagues investigated the association of maternal HIV infection with maternal- and infant-specific antibody levels of Haemophilus influenzae type b (Hib), pneumococcus, Bordetella pertussis antigens, tetanus toxoid, and hepatitis B surface antigen. Between March 2009 and April 2010, antibody levels were measured in HIV-infected and uninfected women and their infants at birth and at 16 weeks, in Khayelitsha, South Africa.
The researchers found that, at birth, HIV-exposed uninfected infants had significantly lower levels of specific antibodies to Hib, pertussis, pneumococcus, and tetanus than did unexposed infants. HIV-exposed uninfected infants had stronger responses following vaccination compared to unexposed infants, with significantly higher antibody responses to pertussis and pneumococcus. HIV-infected women had significantly lower specific antibody levels to Hib and pneumococcus compared to uninfected women; whereas, there were no significant differences in levels of antipertussis or antitetanus antibodies.
"Our data highlight the need for larger prospective studies to determine whether the lower antibody levels in HIV-exposed infants at birth translate into increased morbidity from vaccine-preventable infections," the authors write.
Related Content
S1E4: Dr. Kristina Adams-Waldorf: Pandemics, pathogens and perseverance
July 16th 2020This episode of Pap Talk by Contemporary OB/GYN features an interview with Dr. Kristina Adams-Waldorf, Professor in the Department of Obstetrics and Gynecology and Adjunct Professor in Global Health at the University of Washington (UW) School of Medicine in Seattle.
Listen
Unveiling the complexities of preterm birth risk from nativity, ethnicity, and race
March 22nd 2024A recent study dissected the relationships between maternal nativity, ethnicity, and race in influencing preterm birth rates, shedding light on disparities and suggesting avenues for future research.
Read More
Study reveals link between opioid dosage and spontaneous preterm birth risk
February 21st 2024Recent research highlighted an association between the total dose of prescribed opioids during pregnancy and the heightened risk of spontaneous preterm birth, emphasizing the need for judicious opioid use in pain management for expectant mothers.
Read More