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Review some of the top stories from the Contemporary OB/GYN website over the last week, and catch up on anything you may have missed.

Contemporary OB/GYN week in review: Preeclampsia screening, BV treatment, and more

She joined the MJH Life Sciences team in December 2019. She graduated from Youngstown State University in 2019 with a bachelor's degree in journalism and a minor in political science. Prior to graduating, Morgan worked as the editor-in-chief of her college newspaper. She went on to work as an assignment editor at a broadcast news station in Youngstown, Ohio, before joining 

 You can reach her at mebert@mjhlifesciences.com.

A recent study found that women with colorectal cancer face an increased long-term risk of pain during sex, early menopause, and pelvic disease.

Colorectal cancer tied to long-term sexual health risks in women

A new study suggests a strong association between hyperinsulinemia and abnormal uterine bleeding, pointing to shared risk factors that could inform future prevention and treatment strategies.

Insulin resistance linked to abnormal uterine bleeding

A retrospective study finds comparable pregnancy rates between PPOS and GnRH antagonist protocols, with a trend toward improved blastocyst outcomes in PPOS cycles.

Similar IVF outcomes reported for PPOS and GnRH antagonist protocols

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A Psychedelic to Treat Postpartum Depression?

CMV: In the Know

RSV Roundtable

STIs

Supplement: Closing the Gap in Cervical Cancer Screening

Vaginismus: Managing a Misunderstood and Underdiagnosed Condition

Why vNOTES Make Sense for My Patients

1rem

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The Early-7 (E7) protein of HPV binds to the underphosphorelated form of the tumor suppressor protein - pRb and displaces the E2F transcription factor that is normally bound by pRb. The latent membrane protein-1 (LMP-1) of EBV prevents apoptosis of B cells by up regulating the expression of bcl-2, and it activates growth promoting pathway that are normally triggered by T cell - derivate signal.

Cervical Cancer with Human Papilloma Virus and Epstein Barr Virus Positive

In a recent interview ObGyn.net conducted for 

 on comprehensive care and cancer screenings at well-woman visits, the topic of stethoscopes came up. Ilene S. Gewirtz, MD, the interviewee, mentioned that she still carries a stethoscope and listens to her patients' heart and lungs at well-woman visits. She also said that she believes she's in the minority regarding this practice. We want to know if she's right.

POLL: Many women consider their OB/GYN their primary care provider. But like your primary care counterpart, do you carry a stethoscope?

Do OB/GYNs Carry Stethoscopes?

Preeclampsia

Eran Bornstein, MD, director of obstetrics and gynecology at Northwell’s Lenox Hill Hospital, discussed the importance of early detection and targeted prevention strategies to reduce the risks associated with preeclampsia. 

Preeclampsia is a serious pregnancy complication affecting 5% to 10% of pregnant women and is a major cause of maternal and fetal morbidity and mortality. A comprehensive first-trimester screening protocol offers the most effective method for identifying women at high risk of developing early preeclampsia, defined as occurring before 37 weeks of gestation.

This first-trimester screening includes a combination of maternal characteristics, biophysical markers, and serum biomarkers. When integrated, these factors create a highly individualized risk assessment. This comprehensive screening detects over 80% of preeclampsia cases before 37 weeks' gestation and more than 90% of cases before 32 weeks, making it significantly more effective than traditional risk-factor-based assessments, which are less specific and result in high false-positive rates.

The test has been validated through large-scale international studies involving tens of thousands of women across various populations, ethnicities, and geographic areas. These studies support the test’s reliability and efficacy, leading many international health organizations to recommend it as the gold standard for preeclampsia screening.

A key benefit of early detection is the potential for effective intervention. Bornstein highlighted low-dose aspirin as a simple and effective treatment for reducing the incidence of preeclampsia, especially when administered to high-risk women identified through first-trimester screening. Aspirin has been shown to significantly reduce the risk of preeclampsia before both 37 and 32 weeks of gestation.

Clinicians can integrate this comprehensive screening into standard first-trimester visits. At that time, patients typically undergo assessments for fetal chromosomal abnormalities such as Down syndrome using nuchal translucency ultrasound and blood tests. By adding uterine artery Doppler measurements, maternal blood pressure, and a thorough medical history, providers can simultaneously screen for preeclampsia risk. 

This approach transforms the first-trimester visit into a holistic evaluation of maternal and fetal health, enhancing early identification and prevention strategies for several complications. Bornstein advocated for broader implementation of this model, which is already in use at institutions such as Lenox Hill Hospital.

Disclosures: Longeviti Neuro Solutions LLC

This video is part 1 of a 2-part series. Click 

Comprehensive first trimester screening can identify over 90% of early preeclampsia cases, allowing timely intervention with low-dose aspirin to significantly reduce risks for both mother and baby.

Clinical

Eran Bornstein, MD explains the need for first trimester preeclampsia screening

These images are from a middle-aged woman with abnormal vaginal bleeding. What’s your diagnosis?


Can you identify the cause of abnormal vaginal bleeding in this middle-aged woman?

Image IQ: Abnormal Vaginal Bleeding

What's your diagnosis in this 3rd trimester fetus?

Challenge your diagnostic skills with this image of a fetal head.

Image IQ: Third Trimester Fetal Head

What is your diagnosis based on these images of the ovary?

Challenge your diagnostic skills with this image quiz: Is this ovarian lesion cystic in nature or something else?

Image IQ: Ovarian Cyst or Something Else?

These are 3D ultrasound images of a 14-week fetus. What is your diagnosis?

occipital meningocele and umbilical hernia

Adi A. Prayitno

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