Adi A. Prayitno

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The Early-7 (E7) protein of HPV binds to the underphosphorelated form of  		the tumor suppressor protein - pRb and displaces the E2F transcription  		factor that is normally bound by pRb. The latent membrane protein-1  		(LMP-1) of EBV prevents apoptosis of B cells by up regulating the  		expression of bcl-2, and it activates growth promoting pathway that are  		normally triggered by T cell - derivate signal. The aims of this study  		to know that in cervical cancer stay HPV and EBV. DNA was isolated from  		nineteen sample cervical cancer tissues frozen section. Diagnose related  		with HPV and EBV was made by Polymerase Chains Reaction (PCR). The  		result of this experiment showed that from 19 samples diagnosed as  		cervical cancer, 17 samples are positive HPV and 13 samples had HPV and  		EBV positive. The conclusion of this experiment is 89% of cervical  		cancers are infected with HPV and 68% also infected with HPV and EBV.

Articles

The Early-7 (E7) protein of HPV binds to the underphosphorelated form of the tumor suppressor protein - pRb and displaces the E2F transcription factor that is normally bound by pRb. The latent membrane protein-1 (LMP-1) of EBV prevents apoptosis of B cells by up regulating the expression of bcl-2, and it activates growth promoting pathway that are normally triggered by T cell - derivate signal.

Author | Adi A. Prayitno

Articles

Cervical Cancer with Human Papilloma Virus and Epstein Barr Virus Positive