Lesa Childers

         PCOS Advisory Board member         

, is a PCOSupport Chapter         Development Coordinator and is the founder of WNC PCOSupport. A great         advocate for PCOS education, Childers meets many doctors and medical         professionals in her work with PCOSupport. This section will highlight         different health professionals discussing their work related to         Polycystic Ovary Syndrome.          

For this installment, Childers discusses Laser Hair Removal  with Dr. Frank McCutcheon, a plastic surgeon in private practice in  Asheville, NC..  Dr. McCutcheon is a member of the American Society of  Laser Medicine and Surgery and has been using laser technology to treat  unwanted hair growth since its approval by the FDA in 1997. 

As a woman  with PCOS who has had to deal with the problem of hirsutism or unwanted  hair growth for many years now, I was thrilled when laser treatment for  hair removal was finally FDA approved.  After the birth of my child in  1999, I was finally ready to address this problem head on.  By this time  I had been coordinating our local PCOSupport chapter for several months  and understood that this is an issue for most women with PCOS.  I  contacted Dr. Frank McCutcheon and asked him to provide an educational  session to our group.  He kindly obliged the group with a wonderful  presentation about laser hair removal and gave us an actual  demonstration of a laser treatment.  Recently, I spent some time  visiting Dr. McCutcheon’s office (one guess as to the reason why) and he  graciously agreed to an interview for this column. 
         
         

Will laser hair removal take away the hair permanently?


         
         Long-term studies have shown that up to 90% reduction in hair  growth at 19 months, the length of these studies so far.  Longer  follow-up will be needed before claims of “permanent” removal can be  made.  But if is clear that very long lasting hair removal is possible.   No laser hair removal system is currently allowed to claim “permanent  hair removal.”
         
         


         
         Yes.  Any hair bearing area on the body can potentially be treated.
         
         

What do I need to do in preparation for the treatments? 


         
         Usually simple clipping or shaving of the area you wish to have  treated is sufficient.  Plucking or waxing the area is not usually  recommended as the laser light is attracted to the dark hair under the skin.
         
         

What if I have recently had the area bothering me waxed or plucked?


         
         Hair should be present in the follicle for laser treatments to  be most effective.  Since waxing or plucking pulls hair out of the  follicle, recently waxed or plucked areas will not be suitable for  treating.  I recommend allowing enough time for the hair shafts to  return to the area of concern before treating.  During the time, you may  shave the area, if you wish. 
         
         

Will laser treatments work better for some people than others?


         
         Although all except the darkest skin types and lighter hair colors  are potentially treatable; it usually works more effectively when used  for the darkest hair against the lightest skin.  People with tans should  wait until their tan has faded before being treated.
         
         


         
         A dye can be applied to the hair just before treating that may  make the laser more effective.  However, treatment of light hair cannot  be expected to be as effective as treatment of dark hair.
         
         


         No.  The laser treatment only works on hair that is in an  actively growing stage.  At any given time an average of 30% of our hair  may be at rest.  When this hair becomes active again it will grow and  require treatment.  Also, growth of completely new hair in an area can  occur with time and require treatment.  This is why women  with PCOS need to consult their primary care provider regarding  medications to keep the hormones in a more normal state so that new hair  growth will be at a minimum for that person. 
         
         

How many treatments will I need?
         


         This is unknown.  Research indicates that an initial series of  3-5 treatments at short intervals, e.g. – 4 weeks, followed by  subsequent treatments as needed may give the best results.  Depending on  the area treated, your personal hair growth characteristics and your  goals, between 3-8 treatments, or more, may be needed to achieve maximum  results.
         
         


         
         No anesthetic is usually required.  For especially sensitive  skin or patients, however, a topical anesthetic cream can be applied in  advance. 
         
         

Are there any side effects or complications?


         
         Areas treated may develop a slightly reddened, irritated  appearance that may last for a few minutes to a few hours.  These areas  may be mildly uncomfortable during this time.  Persons with darker skin  types or who are tanned may experience some lightening of the skin.   This should be temporary. Few other side effects should be likely to  occur.
         
         

Are there any medications I should avoid before the treatment?
         


         Yes, if you are presently taking medications or preparations  that might make your skin more sensitive to light, such as tetracycline  or St. John’s         Wort, you will probably be advised to stop these one to two  weeks before treatment.  Also, many clinics recommend stopping the use  of skin care products  such as         Retin-A, Renova or other glycolic or alpha-hydroxy acid  preparations for a week before your treatment.  The can all result in  your skin being more sensitive than normal to the laser light.
         
         


         
         This will vary from clinic to clinic and most are willing to  provide an estimate of charges to you prior to treatment.  While one  laser treatment is generally more expensive than an electrolysis  treatment, the area treated can be larger and take much less time.

Articles

As a woman with PCOS who has had to deal with the problem of hirsutism or unwanted hair growth for many years now, I was thrilled when laser treatment for hair removal was finally FDA approved.

PCOS and Laser Hair Removal

 is pleased to announce a new interview section with Advisory Board member 

. Childers is a PCOSupport Chapter Development Coordinator and is the founder of WNC PCOSupport. A great advocate for PCOS education,, Childers meets many doctors and medical professionals in her work with PCOSupport. This section will highlight different health professionals discussing their work related to Polycystic Ovary Syndrome. 

Hello Everyone:

I am excited to have the opportunity to speak with Lisa Marasco, IBCLC about her research regarding a possible link between PCOS and Breastfeeding difficulties. In my work as a PCOSupport coordinator and as a new mother, I have met several women with PCOS who have expressed concerns about difficulty breastfeeding related to low milk supply. While many women with PCOS apparently have no problems breastfeeding , my own curiosity regarding a possible link was peaked when I personally was unsuccessful at breastfeeding my daughter. While at the PCOSupport conference in San Diego this year, I heard of Marasco’s study and contacted her for more information. She has kindly agreed to be my first interviewee for this new 

Tell me something about your professional background



I am an International Board Certified Lactation Consultant (IBCLC) in private practice. I've been working with breastfeeding mothers for 15 years, the last 7 professionally. I am also just completing graduate work in human development with specialization in lactation.



I have been told that anybody can breastfeed, is this true?



It is interesting that in the mammalian kingdom, lactation failure due to insufficient milk production is a rare if not unknown phenomena. Yet, it is becoming clear that among humans, there are a small percentage who have not been able to make enough milk to support a baby; current estimates run between 2 and 5%. Among the factors I listed above, most are avoidable and/or reversible. The overall incidence of primary supply failure (no other known cause) should be small, but in my opinion seems to be inexplicably rising.



What got you interested in PCOS and possible breastfeeding problems?



Three years ago, I had two mothers present back-to-back within a week's time with milk supply failure. I had noted in the maternal health history that one had been diagnosed as PCOS, and the other as Stein-Leventhal. At the time I did not know much about either, but intrigued, I began to do research and discovered that they are essentially the same thing. This led me into deeper research as to the causes and hormonal issues of PCOS in the hopes of identifying a common underlying pathology, as well as a potential treatment.



What is the hypothesized incidence of breastfeeding problems in women with PCOS, and how does that compare to the non-PCOS population?



In a recent casual survey of mothers (n=39) from two internet PCO support groups, 67% reported making enough milk while 33% had an insufficient supply. Of the poor production group, 67% produced very little at all. Interestingly, 1 out of 5 mothers in the sufficient supply group complained of problematic overproduction.

In the general population, it has been variously estimated that between 2 and 15% of all women are unable to produce enough milk. Most experts in the lactation field believe the percentage to be less than 5%.




Tell me about your research and how you are doing the study.



This is my second level of research on the issue of PCOS and milk supply, and will be summarized as my master's thesis. The first level involved case studies and hypotheses as to the potential etiologies of the milk supply failures, and was published this past May in the Journal of Human Lactation.

My current study is attempting to take the research a step further by taking a detailed history on mothers with PCOS who have experienced unexplained milk supply failures, preferably as diagnosed by qualified lactation consultants. I am collecting data on each mother's PCOS hormonal and symptomatic profile, her past lactation history, the health and lactation history of her close relatives, and her breast growth and shape history through pregnancy. From this I am hoping to perhaps identify some common factors that can help pinpoint specific issues more accurately. In the future I would like to conduct a full-scale third level that would be a prospective study of identified mothers with PCOS.



If it turns out that to be true that PCOS women have more lactation problems, what is the possible endocrine mechanism?



There are several different ways that PCOS could potentially interfere with lactation. Breast development largely occurs during puberty and pregnancy as the result of estrogen, progesterone, and during pregnancy, prolactin. Estrogen mediates ductal growth, while progesterone mediates alveolar growth. It is well known that many if not all PCOS women are deficient in progesterone; depending upon the onset of PCOS, there is a hypothetical potential for disruption of alveolar growth during adolescence, not to mention during pregnancy. A recent case study in the Journal of Human Lactation noted a mother who was diagnosed with lactation failure due to insufficient mammary tissue who developed more breast tissue with her second successful pregnancy after treatment of secondary infertility with pre- and post-conception progesterone therapy; she went on to produce a full supply of milk. This case seems to lend credence to the progesterone deficiency theory.

In addition to the progesterone contribution to breast development, there are also the hormones estrogen and prolactin. While estrogen levels can be high in the peripheral tissues of some PCOS women, it has also been noted that androgens, which are generally high with PCOS, can down-regulate both estrogen and prolactin receptors. In essence, a woman could produce enough hormones but not have enough receptors to utilize them, thus limiting their influence upon breast tissue.

Another level of potential disruption lies in the lactation process itself. It is believed that the drop in progesterone at parturition serves to initiate production of mature milk. As this occurs, a process takes over which is driven by two major hormones, prolactin (affects production) and oxytocin (affects delivery). Prolactin receptors begin to develop during pregnancy, and then continue to multiply during the early postpartum period in proportion to the frequency of nipple stimulation. If receptor development was inhibited, the effectiveness of the circulating hormone would be diminished, thus limiting milk production.

Estrogen is a known inhibitor of milk production, especially in the early postpartum period. If the receptors are not down-regulated and the circulating estrogen levels are high, this too could potentially disrupt lactation.

Insulin also plays a vital, though less well-known, role in milk production. Women with uncontrolled diabetes mellitus will not make enough milk. Given this fact, what might be the effect of insulin resistance, which appears to be a significant factor in PCOS, upon lactation? The breast is a sensitive target organ for insulin; if insulin cannot be taken in quickly and efficiently enough, this too could hypothetically cause lactation problems.



What is the macronutrient composition of human milk in women with PCOS compared to women without PCOS?



The composition of milk from women with PCOS has not been studied.



Could the potentially high carbohydrate composition of human breast milk contribute to insulin resistance in children?



This is highly unlikely. Mammalian milk is species-specific, providing the exact nutrients necessary for optimal growth of each species. The majority of the carbohydrate in human milk is in the form of lactose, which serves to enhance calcium absorption as well as provide a ready energy source for the rapidly growing infant brain. It is interesting to note that human babies make large amounts of lactase, enzymes which break down lactose, for the first couple of years of life, after which the production of these enyzmes diminishes greatly. This suggests that lactose is an important nutritional source for the human infant, but not for older humans.

This raises some intriguing questions. If we are not built to process a lot of lactose after infancy, what might be the ramifications of a diet high in dairy? It is well known that many populations are lactose intolerant; we also know that early introduction of cow's milk has been associated with an increased incidence of diabetes. Might diets heavy in dairy/lactose contribute to the development of insulin resistance which seems to be becoming almost epidemic? The question of the healthiness of carbohydrates in general in the human diet is a good one, but must also be balanced out with nature's intended nutritional blueprint over our lifespan, during which our needs change.



What are the usual reasons for low milk supply in new mothers?



The number one cause of low milk supply is simple "mismanagement", meaning baby is not latched properly over the long term, or mother and baby are not breastfeeding often enough, resulting in inadequate stimulation for good milk production. Close behind is "perceived insufficient milk supply", which refers to the cultural perceptions that cause mothers to conclude that they are not making enough milk when indeed they are and can. This misperception often occurs during growth spurts, or from the ignorant and worrisome comments of friends and relatives about how often baby "should" be eating or how long baby "should" be sleeping at a particular age, resulting in a decision to supplement that causes baby to demand less and thus milk production to truly drop.

Beyond this, hypothyroidism, uncontrolled diabetes, or more rarely retained placental fragments or severe postpartum hemorrhage, can also cause low milk supply, as can birth control pills and shots, especially when started early on.



How does mother's diet affect milk production?



A mother who is well-nourished will usually produce abundant milk, but even a less well-nourished woman will generally produce enough milk to sustain her infant. A mother's body puts on an average 5-10 pounds of adipose tissue during pregnancy which is intended as a source of nutrients and energy if the food supply is scarce. Thus, though the production may be lower in times of scarcity, mothers should still be able to make enough milk to support their infant, given an adequate supply of fluids.



What is the composition of human milk (%carbohydrate, protein, fat) compared to non-human primate breast milk?



Human milk is approximately 4% fat, .9% protein, and 7% carbohydrate (mainly lactose), whereas baboon milk is approximately 5% fat, 1.6% protein, and 7.3% carbohydrate. 



Does breast size matter in relation to breastfeeding and milk supply?



Generally speaking, no. I've seen moms with small breasts produce copious amounts of milk. For the most part, breast size mostly determines storage capacity, not potential milk production. Women with large breasts tend to produce milk at slower rates since they can store a lot, whereas women with small breasts will produce milk at faster rates in order to meet the needs of the infant, who will "drain the tanks" quickly. The difference usually shows up as a baby who takes "large meals" less often, versus a baby who takes "smaller meals" more often. If nature is allowed to take its course and baby feeds as often as he needs to, both mothers usually can make enough milk to feed their babies.



What is breast hypoplasia and what are the causes?



Breast hypoplasia is the technical term referring to underdevelopment of the breast. We also often refer to this as "insufficient mammary tissue", because it is the inadequate development of the glandular tissue that is a problem more than mere size. Hypoplastic breasts can vary in cup size but often have an "empty sac" look to them, rather than the normal filling out of the breast. It is not unusual to see one breast markedly larger than the other, more than the usual small asymmetry.

There are some rare genetic problems such as Poland's syndrome than are related to breast hypoplasia, but they usually involve deficiencies of the underlying pectoral muscles. When we discuss the phenomena of insufficient mammary tissue, these rare syndromes have been ruled out, and unfortunately we do not yet have answers to what might be the cause of the remaining cases of hypoplasia. It does seem feasible that, since hormones are responsible for breast growth during adolescence and pregnancy, some kind of hormonal problem may be involved; however, we have not found any specific correlations to date.



What are your suggestions to postpartum mothers who are having difficulty with breastfeeding?



All mothers should be aware of their community breastfeeding resources, and they should not hesitate to contact a qualified counselor if they are having problems. I would strongly encourage women who have had past health or fertility problems to line up a professional lactation consultant, preferably IBCLC, in advance, and to arrange for a consultation at the first sign of possible problems. Early intervention can be very important in some cases.



Can other women with PCOS join the study?



Though my thesis will be finalized soon, I will continue to collect and collate responses to my questionnaire. Women with PCOS who would like to participate in future studies (not necessarily mine) can register at a newly established website: 

. Researchers from all over the world will have potential access to this database, which will hopefully speed up studies on lactation-related issues, including those that touch moms with PCOS.

I am excited to have the opportunity to speak with Lisa Marasco, IBCLC about her research regarding a possible link between PCOS and Breastfeeding difficulties.