Tommaso Falcone, MD

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Uterine transplantation (UTx) has rapidly moved from a theoretical construct to a clinical reality. Over just the past 5 years, the world has witnessed several notable milestones in this quickly-evolving field. With healthy live birth being the ultimate goal of a reproductive transplant, the 14 babies born to date following UTx for which reports exist and the additional ongoing pregnancies represent proof of concept for the viability of this experimental procedure. 


	UTx represents the first and only treatment for women with absolute uterine factor infertility (

) or acquired. Estimated to affect one in 500 women, AUFI has previously only been addressed using in vitro fertilization (IVF) with gestational carriers, fostering, adoption, or planning a life without children.

 For some women, these may be acceptable options, but for others, these alternatives may not be desired, often due to personal, social, cultural or religious beliefs. Choices for women with AUFI are especially limited in parts of the world where gestational carriers and even adoption may be socially unacceptable, highly restricted, or banned completely. Interviews of women with AUFI in a uterine transplant trial indicate that the diagnosis of AUFI can be a devastating and life-altering experience and that achieving reproductive autonomy is a key desire of women with this condition.


	The advent and rapid ascent of UTx have been marked by innovation. Initial international attempts in humans performed outside of clinical trials were not successful, and technical success for the Swedish team was ultimately achieved following decades of preparatory work in small mammals and non-human primates. As with any new surgical procedure, the technical elements have quickly advanced and evolved (Table 1). 

Uterine transplantation from deceased donor results in livebirth

Together with documented technical success and increased media attention has come improved public perception and enhanced physician awareness and support for the procedure. Sixty percent of A

merican Association of Gynecologic Laparoscopists

American Society for Reproductive Medicine

ASRM) members support UTx as a treatment for AUFI.

 of public perception of UTx in the United States indicated that 78% of respondents supported UTx and 45% believed it should be covered by insurance.

 indicated that 74% of women would donate their uterus for transplant.

 It is unclear what the cost of a uterine transplant will be, and how or whether insurance will cover this reproductive procedure. As the discussion evolves along with the science, questions regarding access, cost, and safety will be paramount. 

Slow initial acceptance of UTx may be due to the fact that, unlike other transplants, UTx is not a life-saving transplant. Like face, hand, and other vascularized composite allographs, the uterine transplant can be life-enhancing and indeed can be life-giving. Also distinct from other known organ transplants, UTx is an “ephemeral” transplant.

 This means that the uterus will be removed after one or two live births are achieved and is not intended to be a lifelong transplant. This means that women receiving a UTx will not be exposed to immunosuppression once the uterus has been removed after childbearing. 

Despite growing numbers of live births, UTx remains a significant undertaking for both recipients and living donors. The procedure for donor hysterectomy is similar to radical hysterectomy, and donor complications have been reported in the literature.

 Historically, donor surgeries have involved long operating room times (10-13 hours in the original Swedish series) and large incisions, although this may change as laparoscopic and robotic approaches are pioneered. Although a deceased donor model obviates this risk completely, most live births to date have been achieved with living donors. Deceased donor UTx represents a more ethical choice by eliminating donor risk, however, it has the limitations of organ availability, less convenient scheduling, and more restricted medical history on the donor.

 It is unknown how outcomes from deceased donor trials will compare with living donor trials and whether one approach will demonstrate superiority over the other or whether both approaches will coexist. Recent studies suggest no recipient preference for a living vs a deceased donor.


	Risks to the recipient are also currently being determined in clinical trials. The major risk is hysterectomy, due to either infection or graft thrombosis. Although data on clinical outcomes and complication rates are still very limited, in the original Swedish trial, two of nine patients (22%) required hysterectomy prior to attempted embryo transfer.

 After IVF to create embryos and listing for transplant, the recipient must undergo three or four separate major abdominal procedures including uterine implantation, cesarean delivery (possibly x 2), and then hysterectomy to remove the graft. In addition, immunosuppression in the recipient carries risks and side effects during treatment that a young and healthy woman would not normally need to manage. Registries of pregnancy with other solid organ transplants have supported the safety of the immunosuppressive regimens used for UTx in relation to fetal and neonatal well being. 

Careful screening, selection and counseling of UTx recipients and their families is necessary in the context of a clinical trial. As such, a UTx team must consist of a broad range of subspecialists at an academic center with a capability for longitudinal follow-up (Table 2). At this point, uterine transplant is still experimental and should only be conducted under an IRB-approved research program.

 As “success” with uterine transplant has multiple endpoints (graft viability, onset of regular menses, and embryo implantation, pregnancy, and ultimately delivery of a healthy neonate) that may occur over several years, a multidisciplinary team must be in place that can conduct years of surveillance of mothers and infants. 


	Many aspects of a UTx program are complex, but by far the most challenging aspect is surgical retrieval of the uterus and implantation of the graft into the recipient. Development of safe surgical techniques that optimize graft performance is of great interest within clinical trials of UTx, including our own at the 

. A successful graft (whether from a living or deceased donor) must have adequate circulatory inflow and outflow. This optimizes functionality and prevents ischemia and thrombosis, which are major causes of graft failure worldwide in UTx.

 A well-functioning graft will be able to tolerate the increased demands of uterine blood flow during pregnancy, which represents one-sixth of the cardiac output. Preventing infection and rejection are also key considerations in the perioperative and post-transplant period. 

In a living donor model, obtaining adequate vascular support for the transplanted uterus must be balanced against potential risky dissections in the deep pelvis, which can compromise the ureter, nerves, or blood vessels in this area of the donor. Genitourinary complications have been reported in living donor trials from Sweden, Texas, and Saudi Arabia.

 The major difficulty is complex dissection of the uterine vessels, notably the branching uterine veins that lie in proximity to the ureter. Due to these concerns and reported injuries, the exclusive use of the utero-ovarian vein has been successfully applied and has resulted in a live birth in the United States.

Use of these kinds of vessels has made an easier transition to development of laparoscopic and robotic approaches as well.

Given the rapid pace of the last 5 years, what will the next decade hold for this dynamic and innovative field? We anticipate ongoing progress and refinements in the spirit of innovation that characterized development of this reproductive procedure. Living donor surgeries are already becoming shorter and less risky, involving more minimally invasive techniques such as robotics and laparoscopy and innovative vascular support that avoids extensive pelvic dissections in donors. Women (mothers, sisters and friends) should not have to feel pressure to undergo lengthy and potentially risky surgeries to help alleviate suffering of a loved one with AUFI. We can envision that donor procurement may evolve to a 4- to 6-hour completely minimally invasive hysterectomy with a one-night hospital stay and relatively low risk of complications. However, in pursuit of minimally invasive approaches using the ovarian vessels, we must be cautious to avoid removing the ovaries in donors, as this can have significant long-term health consequences.

In deceased donor studies, we anticipate additional live births from our center and others. With more births from deceased donor transplants, we will be able to more directly compare outcomes related to deceased versus living donor models. Further bioethical analysis will be needed to consider risks to mothers, offspring, and donors/donor families. Reducing ischemia time and increasing the availability of suitable donor uteri (e.g., using “increased-risk” donors, widening recovery radius), and enhancing preservation and perfusion techniques to reduce the effects of ischemia are key areas of interest. 

For recipients, we anticipate reduced immunosuppressive regimens and shorter times to embryo transfer to reduce exposure to immunosuppression. As additional reassuring data on obstetrical and neonatal wellbeing emerge, we anticipate more widespread understanding and acceptance among physicians and the general public. International organizations such as the 

International Society for Uterine Transplantation

 (ISUTx) have fostered collaborations between research centers

 with the recent annual meeting at the Cleveland Clinic in September 2019; a registry is forthcoming to more rigorously collect data regarding procedures and outcomes. Looking ahead, as experimental trials will have limited funding for UTx and there is ongoing demand, we hope to expand access by continuing discussions with the public, employers, and insurance companies regarding cost and coverage for the surgical correction of an otherwise incurable condition that carries significant personal, marital, and social harm. 

Further areas for future discussion will include options for spontaneous pregnancy with tubal transplant along with the transplanted uterus, the likely emergence of uterine transplant for trans women, and the possibility of a bioengineered uterus or uterine xenotransplantation. 


	Although UTx remains a technically challenging and complex undertaking, our comprehension of this procedure has made extraordinary progress in a very brief time. Insights and basic science efforts for UTx research extend beyond uterine transplantation itself; in doing this work we may begin to apply our understanding to mechanisms of embryo implantation, early pregnancy and uterine receptivity, reproductive and placental immunology, and numerous other aspects of obstetrics and gynecology. Although the field is still early in its evolution, UTx is leading us into a new and exciting era of reproductive transplantation which has wide-ranging applications. 

The authors report no potential conflicts of interest with regard to this article.

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