
Women who use oral contraceptives (OC) or hormone replacement therapy (HRT) have a two- to sixfold increased risk of a venous thromboembolic event (VTE) compared with nonusers, according to a recent review of available data. Users of OCs containing desogestrel or gestodene, as opposed to levonorgestrel, are at slightly higher risk. And users of OCs or HRT who carry an inherited hypercoaguable state are at exponentially higher risk.