In breast discharge, mammogram unremarkable but ductography definitive
A 54-year-old patient presented for evaluation of spontaneous left breast discharge. The patient is status post-right mastectomy with TRAM reconstruction in 1999. The patient states she has noted left breast discharge for quite some time
Clinical History
A 54-year-old patient presented for evaluation of spontaneous left breast discharge. The patient is status post-right mastectomy with TRAM reconstruction in 1999. The patient states she has noted left breast discharge for quite some time.
Findings
Mammography reveals postsurgical changes from TRAM reconstruction in the right breast. The left breast reveals no abnormality (Figures 1A and 1B).
Upon examination, discharge was expressed from two ducts in the left breast. In the central portion of the left nipple, a brownish discharge at 12 o’clock was present and, in addition, a clear discharge in the left 6 o’clock portion of the nipple. Slides were obtained and sent for pathology.
A left ductogram was performed; the left breast duct in the 12 o’clock area of the nipple was cannulated centrally and the duct opacified with contrast (Figure 2A and 2B). This revealed multiple areas of intraluminal masses throughout the ductal system (Figure 2C).
Breast MRI for extent of disease revealed extensive diffuse enhancement involving the entire breast (Figure 3). This enhancement extends from the nipple to the chest wall.
Diagnosis
Pathology of the left nipple discharge revealed atypical ductal epithelium. Stereotactic core biopsy of the ductographic abnormalities was also performed. Pathology revealed ductal carcinoma in situ, nuclear grade 3.
Discussion
This case demonstrates the importance of a complete work-up when a patient presents with discharge, including mammography and ductography. In this case, the mammogram was unremarkable; the ductogram revealed multiple intraluminal masses, which upon biopsy proved to be carcinoma. Dr. Destounis is managing partner and a radiologist at Elizabeth Wende Breast Care in Rochester, NY.
Reprinted from DiagnosticImaging.com
Original Article: In breast discharge, mammogram unremarkable but ductography definitive
Related Material
- Ultrasound Interactive Case Study:Infiltrating Ductal Carcinoma of Breast
Exogenous hormones and patients at increased risk for breast cancer
October 17th 2023This lecture, presented by Holly J. Pederson, MD, at The Menopause Society 2023 Annual Meeting, looked at combined oral contraceptives in BRCA carriers and other high-risk patients, and hormone therapy in postmenopausal gene carriers as well as other high-risk women.
Read More
Hormone replacement therapy does not increase breast cancer recurrence, mortality in survivors
July 20th 2022An analysis of data from more than 8400 postmenopausal women with a history of early-stage nonmetastatic, ER-positive breast cancer suggests there was no increase in risk of breast cancer recurrence or mortality observed with use of vaginal estrogen therapy or menopausal hormone therapy.
Read More
