Common hereditary cancer syndromes with breast and gynecologic malignancies

August 30, 2019

DR. MODESITT is an Associate Professor and Chief, Division of Gynecologic Oncology, Obstetrics and Gynecology Department, University of Virginia Health System, Charlottesville, VA.

, Christine Garcia, MD

Christine Garcia, MD

Dr. Garcia is a Fellow in the Gynecologic Oncology Division, Department of Obstetrics and Gynecology, at the University of Virginia in Charlottesville.

As they often serve as primary care providers, ob/gyns are uniquely positioned to help identify at-risk women before they develop cancer.

As they often serve as primary care providers, ob/gyns are uniquely positioned to help identify at-risk women before they develop cancer. Identification of these women is important so they may be offered increased screening or risk-reduction measures that have proven benefits for improving survival. These are some of the most common syndromes related to breast and gynecologic cancers.

For more information - Hereditary cancers in gynecology: What clinicians need to know

BRCA

1/300-800 Ashkenazi: 1/40

Breast, ovary, melanoma, prostate, pancreatic

RAD51C
RAD51D
BRIP1

Unknown

Ovary

MLH1
MSH2
MSH6
PMS2
EPCAM

1/660-2000

Uterine, colon, ovary, pancreatic, gastric, small intestine, central nervous system, renal, sebaceous

PTEN

1/200,000

Breast, uterine, thyroid, colon, renal, sebaceous

P53

Unknown

Sarcomas, breast, adrenal, lung, endometrial

STK11

1/25,000-30,000

Gastrointestinal, breast, ovarian, sex cord stromal, uterine, cervical (adenoma malignum)

Common hereditary cancer syndromes with breast and gynecologic malignancies

Susan C. Modesitt, MD

Christine Garcia, MD