Haywood Brown, MD & Jennifer Hoskovec explain new non-invasive confirmatory test

Announced at the 2026 American College of Obstetricians & Gynecologists (ACOG) Annual Clinical & Scientific Meeting, BillionToOne launched Unity Confirm, a non-invasive confirmation test that utilizes circulating fetal cells to verify high-risk prenatal screening results.

Designed to provide diagnostic insights from a maternal blood draw, the test offers a potential alternative to invasive procedures such as chorionic villus sampling (CVS) or amniocentesis for patients who receive high-risk findings during initial aneuploidy screening. Beginning May 28, 2026, clinicians using the Unity Aneuploidy Screen will have access to Unity Confirm following a high-risk result.

In the video above, Haywood Brown, MD, Chief Medical Officer of Prenatal and former president of ACOG, along with Jennifer Hoskovec, MS, CGC, who serves as BillionToOne’s VP of Medical Affairs, joined us at ACOG to discuss the launch and explain the Unity Confirm test.

According to ACOG, “there is a very small chance of pregnancy loss with amniocentesis.” According to the medical society, CVS carries a “slightly higher” chance of miscarriage than amniocentesis.³ Because of these small chances of pregnancy loss, some patients may choose to decline these diagnostic approaches. This is where the circulating fetal cell-based confirmation test aims to fill the gap.

“A high-risk NIPT result does not give you a diagnosis. It gives you a decision to make under enormous stress, often without enough information,” Brown said previously in a statement. “For too long, the options were limited: forgo confirmation, or undergo an invasive procedure with a small but real risk. What makes Unity Confirm truly different is not just the science; it is that this capability is now clinically accessible. That's not an incremental improvement. That is a fundamentally different standard of care."

Reference:

Fitch J. Unity Confirm fetal cell-based test launches for non-invasive confirmation of high-risk prenatal screening results. Published May 2, 2026. Accessed May 8, 2026. https://www.contemporaryobgyn.net/view/unity-confirm-fetal-cell-based-test-launches-for-non-invasive-confirmation-of-high-risk-prenatal-screening-results