News|Articles|September 23, 2026

Menopause proteomic scores associated with cognitive aging, dementia risk

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Menopause proteomics were consistently associated with inflammatory brain aging and Alzheimer’s dementia risk across nearly 15,000 women in a new study published in Nature Medicine.

Using blood proteomics data from multiple cohorts to identify biological changes associated with menopause, the researchers of a new study published in Nature Medicine found that “spontaneous menopause is characterized by dysregulation in inflammatory, synaptic, metabolic, and Alzheimer’s disease biologic processes, which tracked more strongly with hormones than with age.”

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