Prenatal maternal distress impairs newborn amygdala growth

Article

This article is on based on information presented at the Society for Maternal-Fetal Medicine’s 2021 Virtual Annual Meeting, which will be held from Jan. 25 to Jan. 30.

For more information and registration details, visit SMFM.org

A study presented at SMFM’s 2021 Virtual Annual Meeting found that prenatal maternal mental distress is associated with impaired amygdala growth in newborns and impacts cognitive and motor skills in infants at 18 months.

Researchers from Children’s National Hospital in Washington, DC investigated whether prenatal maternal stress, anxiety and depression were associated with postnatal brain growth and infant neurodevelopmental outcomes at 18 months.

Of 116 women, 96 completed mental distress measures twice at different gestational ages (32.0±4.5, 23-40 gestational weeks). 101 newborns underwent postnatal MRI (41.9±1.9, 38-47 gestational weeks); and 87 infants completed neurodevelopmental testing at 18 months.

Evaluations of prenatal maternal stress, anxiety, and depression used the Perceived Stress Scale, Spielberger State-Trait Anxiety Inventory, and Edinburgh Postnatal Depression Scale, respectively.

Neonates were scanned on a 3T MRI scanner with an 8-channel hi-res brain array receive-only coil. Neonatal brain MR images were segmented into cortical grey matter, white matter, deep grey matter, cerebellum, brainstem, left and right hippocampus and amygdala via Draw-EM pipeline. Infant neurodevelopment was evaluated via Bayley Scales of Infant and Toddler Development III at 18 months.

They found that prenatal maternal anxiety was associated with a smaller left and right amygdala in newborns, and lower cognitive scores in infants at 18 months. Prenatal maternal stress was also associated with decreased cognitive and motor scores at 18 months.

Related Videos
Addressing racial and ethnic disparities in brachial plexus birth Injury | Image Credit: shrinerschildrens.org
Innovations in prenatal care: Insights from ACOG 2024 | Image Credit:  uofmhealth.org.
The impact of smoking cessation on pregnancy outcomes | Image Credit: rwjmg.rwjms.rutgers.edu
Maximizing maternal health: The impact of exercise during pregnancy | Image Credit: cedars-sinai.org
The importance of nipocalimab’s FTD against FNAIT | Image Credit:  linkedin.com
Fertility treatment challenges for Muslim women during fasting holidays | Image Credit: rmanetwork.com
CDC estimates of maternal mortality found overestimated | Image Credit: rwjms.rutgers.edu.
Study unveils maternal mortality tracking trends | Image Credit: obhg.com
How Harmonia Healthcare is revolutionizing hyperemesis gravidarum care | Image Credit: hyperemesis.org
Related Content
© 2024 MJH Life Sciences

All rights reserved.