Selective serotonin reuptake inhibitors linked to loss of bone density

Article

SSRIs have been linked to bone density loss that can result in hip fractures and falls, according to two studies published in the June 25 issue of the Archives of Internal Medicine.

SSRIs have been linked to bone density loss that can result in hip fractures and falls, according to two studies published in the June 25 issue of the Archives of Internal Medicine.

Susan Diem, MD, of the University of Minnesota in Minneapolis, and colleagues sampled the bone mineral density (BMD) of 2,722 women with an average age of 78.5, of which 198 used SSRIs for depression. The investigators found an average BMD decrease of 0.82% in hip bones of women taking SSRIs, nearly double the 0.47% bone loss for those taking tricyclic antidepressants or no medication.

In similar research by Elizabeth Haney, MD, of Oregon Health & Science University in Portland, Ore., and colleagues, BMD was measured in 5,995 men aged 65 and older, including 160 who used SSRIs, 99 who took tricyclic, and 52 who used trazodone antidepressants. The researchers found hip and lumbar spine BMD to be 3.9% and 5.9% lower, respectively, for SSRI users than for the rest of the cohort group.

Diem SJ, Blackwell TL, Stone KL et al. Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. Arch Intern Med. 2007;167:1240-1245.

Recent Videos
Rossella Nappi, MD, discusses benefits of fezolinetant against vasomotor symptoms | Image Credit: imsociety.org
How AI is revolutionizing breast cancer detection | Image Credit: simonmed.com
Understanding cardiovascular risk factors in women | Image Credit: cedars-sinai.org.
Christie Hilton, DO, discusses breast cancer management | Image Credit: findcare.ahn.org
Updated FLUBLOK label expands influenza vaccine options for pregnant women | Image Credit: mass-vaccination-resources.org
Sheryl Kingsberg, PhD: Psychedelic RE104 for postpartum depression
Mammograms may reveal hidden cardiovascular risks, study finds | Image Credit: providers.ucsd.edu
Erika Hamilton highlights emerging breast cancer trends and advances in treatment | Image Credit: sarahcannon.com
JoAnn Pinkerton discusses elinzanetant's crucial role in VMS therapy | Image Credit: uvahealth.com
© 2024 MJH Life Sciences

All rights reserved.