Single dose of methotrexate enough for unruptured ectopic pregnancy

September 1, 2006

A single methotrexate (MTX) injection is as effective as multiple doses for managing unruptured ectopic pregnancy, according to the results of the first randomized, prospective study to compare the two medical regimens.

A single methotrexate (MTX) injection is as effective as multiple doses for managing unruptured ectopic pregnancy, according to the results of the first randomized, prospective study to compare the two medical regimens.

Of 54 women who received a single dose of the folic acid antagonist, 48 responded (88.9%). Of 54 women receiving multiple injections, 50 responded (92.6%), for a difference that was not statistically significant (P=0.7; OR 0.64; 95% CI; 0.17–2.4).

The complication rate was also similar; 27.8% of the single-dose group and 37% of the multi-dose group experienced complications (P=0.3).

Alleyassin A, Khademi A, Aghahosseini M, et al. Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial. Fertil Steril. 2006;85:1661-1666.